Figure 1.

An Eph-induced signaling cascade prevents cytokinesis completion: possible physiological and pathological consequences. Activation of Eph signaling in dividing cells interrupts or delays cytokinesis which increases the fraction of polyploid cells. In the neocortex polyploid neurons could participate in generating neuronal diversity while in other tissues, cytokinesis defects could increase genomic instability and participate in tumor initiation.