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. 2017 Mar 9;9:24. doi: 10.1186/s13073-017-0415-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Differential expression with IMQ treatment. a Number of expressed protein-coding genes. b Number of differentially expressed genes (DEGs; IMQ-increased, fold change (FC) >2.0 with FDR <0.10; IMQ-decreased, FC <0.50 with FDR <0.10). c FC distributions (IMQ/CTL). Boxes outline the middle 50% of FC estimates (whiskers, 10th and 90th percentiles). d, e Genes most frequently increased (d) or decreased (e) by IMQ treatment. f, g Gene Ontology biological process terms significantly overrepresented among genes most frequently increased (f) and decreased (g) by IMQ. Values in parentheses (left margin) indicate the total number of IMQ-increased (f) or IMQ-decreased (g) genes associated with each term. The right margin lists example IMQ-increased/decreased genes associated with each term. F female, M male