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. 2004 Nov 16;101(47):16525–16530. doi: 10.1073/pnas.0407574101

Fig. 2.

Fig. 2.

Insulin-regulated versus diabetes-regulated gene expression. (a) Comparison of gene expression in Lox-STZ diabetic and MIRKO mice. The log of the ratios of the expression (experimental group/control) of genes that are changed significantly in either MIRKO or the Lox-STZ when compared with the Lox control are plotted on a log scale (every 0.3 units on the scale equals a 2-fold change). This comparison separated the genes into four quadrants, each reflecting either a concordant or discordant regulation of the genes by the loss of insulin-receptor-mediated signaling and the diabetic state. The genes labeled A and D, for example, were altered in diabetes, but they were not altered by a pure loss of insulin action in the MIRKO mouse; in contrast, the genes labeled B and C were altered in the MIRKO mouse but not in STZ diabetes. (b) The log of the ratios of the expression (experimental group/control) of genes that are changed significantly in either the MIRKO or the MIRKO-STZ when compared with the Lox control. The diagonal black line indicates the line of unity.