Table 1. Genes significantly down-regulated in diabetes with intact (third column) or without (fourth column) insulin-receptor-mediated signaling.

GenBank accession no.	Gene/protein name	Fold change in Lox-STZ/Lox	Fold change in MIRKO-STZ/Lox
Metabolism-related
AI843232	3-Oxoacid CoA transferase	0.55	0.60
AW047743	Isovaleryl coenzyme A dehydrogenase	0.63	0.70
AI853855	Complex I	0.66	0.70
AF010499	Guanidinoacetate methyltransferase (creatine synthesis)	0.66	0.63
AI181132	Creatine kinase precursor, mitochondrial	0.67	0.67
AF080469	Glucose-6-phosphatase, transport protein 1	0.68	0.60
AI848871	Complex I	0.69	0.73
U13841	Complex V	0.69	0.72
AW123802	Complex I	0.71	0.77
U15541	Complex IV	0.71	0.76
AI849803	Complex I	0.74	0.77
AI849767	Complex V	0.74	0.71
AF029843	Phosphoglycerate mutase muscle-specific subunit	0.77	0.83
AI853523	Complex III	0.78	0.70
AF037371	Complex IV	0.79	0.80
X53157	Complex IV	0.82	0.82
AW061302	Complex III	0.84	0.73
U77128	Complex V	0.88	0.80
AI852862	Fumarate hydratase 1	0.90	0.90
Signaling-related
AI836322	Similar to RhoGDI-1	0.66	0.68
Transcription/translation-related
M98036	Eukaryotic translation initiation factor 2B	0.75	0.77
AI854467	SD23 homolog	0.77	0.79