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. 2004 Nov 16;101(47):16525–16530. doi: 10.1073/pnas.0407574101

Table 2. Genes significantly up-regulated in diabetes with intact (third column) or without (fourth column) insulin-receptor-mediated signaling.

GenBank accession no. Gene/protein Fold change in Lox-STZ/Lox Fold change in MIRKO-STZ/Lox
Metabolism-related
AF017175 Carnitine palmitoyltransferase 1, liver 2.31 2.00
AI840013 Peroxisomal delta3, delta2-enoyl-coenzyme A isomerase 1.78 1.64
AW125884 Acetyl-coenzyme A synthetase 2 1.49 1.50
AI846600 Monoglyceride lipase 1.24 1.27
Signaling-related
AI836322 Protein tyrosine phosphatase, nonreceptor type 1 1.76 1.49
AW049031 Immediate-early response, erythropoietin 1 1.73 1.72
M19381 Calmodulin 1.42 1.26
J02626 Similar to protein kinase, cAMP-dependent, catalytic, β 1.37 1.27
U22324 Fibroblast growth-factor receptor 1 1.28 1.35
Transcription/translation-related
AF038939 Paternally expressed gene 3 1.89 1.88
AA960603 Butyrate response factor 2 1.52 1.54
AI846060 Zinc finger RNA binding protein 1.47 1.47
U00431 High-mobility group protein 1 1.43 1.30
AI835685 Splicing factor pRP 8 1.40 1.30
X98511 Similar to splicing factor, arginine/serine-rich 2 (SC-35) 1.39 1.43
Transport/trafficking-related
AI839718 Microsomal signal peptidase 23 kDa 2.12 3.00
AI843574 Homolog to signal recognition particle α subunit (docking protein α) 1.44 1.17
AI835359 Translocon-associated protein γ (TRAP-γ), signal sequence receptor γ 1.39 1.33