Table 3.

Baseline characteristics and risk factors in CeAD patients with or without rare CNV affecting cardiovascular system development. Adjusted p-values and OR (odds ratio) are from a logistic regression analysis adjusted for age and sex. 95% CI = 95% confidence interval of OR. Values are n (%) or mean ± standard deviation, CeAD = cervical artery dissection, ICAD = internal carotid artery dissection, FH = family history, unrelated = related patients were excluded.

	Patients with rare CNVs affecting cardiovascular system development	Other patients

	(n=22)	(n=811)	p-value	Adjusted p-value	OR	[95% CI]
Age	42.8 ± 10.4	44.3 ± 9.9	0.494
Female sex	10 (45.5)	343 (42.3)	0.828
Stroke	16 (72.7)	522 (64.4)	0.503	0.425	1.47	[0.57 – 3.81]
ICAD	13 (59.1)	547 (67.4)	0.490	0.501	0.74	[0.30 – 1.79]
Multiple CeAD	1 (4.5)	124 (15.3)	0.230	0.184	0.25	[0.03 – 1.91]
Hypertension	5 (22.7	214 (26.6)	0.810	0.815	0.88	[0.31 – 2.51]
Hypercholesterolemia	4 (18.2)	153 (19.3)	1.000	0.955	1.03	[0.33 – 3.23]
Migraine	9 (40.9)	300 (37.5)	0.824	0.811	1.12	[0.46 – 2.72]
BMI	25.0 ± 6.4	24.6 ± 3.9	0.743	0.469	1.04	[0.94 – 1.15]
Previous trauma	8 (36.8)	328 (41.2)	0.827	0.592	0.78	[0.32 – 1.91]
Previous infection	7 (31.8)	150 (18.9)	0.165	0.134	2.02	[0.81 – 5.04]
smoking	1 (50.0)	418 (52.2)	1.000	0.916	0.96	[0.41 – 2.25]
FH of CeAD	2 (10.5)	5 (0.7)	0.011	0.001	18.5	[3.3 – 103]
FH of CeAD (unrelated)	1 (5.6)	4 (0.5)	0.110	0.036	11.2	[1.17 – 107]