Shikonin |
Lithospermum erythrorhizon Siebold & Zucc. |
breast cancer MCF-7 cells, osteosarcoma cells, glioma cells, multiple myeloma and leukemia cells |
Induced RIPK-1 and RIPK-3 |
[279, 280, 279, 287-299] |
Piperlongumine |
Piper longum |
malignant breast tumors in xenografted mice in vivo
|
ROS production |
[300] |
Acetogenin mimic AA005 |
Annonaceae |
colorectal adenocarcinoma SW620 cells |
ROS production; induced RIPK-1 |
[301] |
Eupomatenoid-5 |
Piper regnellii (Miq.) C. DC. var. regnellii |
kidney cancer 786-0 cells |
necrosis morphology |
[302] |
Parthenolide |
Tanacetum parthenium |
acute promyelocytic HL-60 cells; Jurkat T lymphoma cells; breast cancer MDA-MB231 cells |
Activation of ROS and RIPK-1 |
[304-307] |
γ-Tocotrienol, |
vitamin E derived from palm oil |
colon cancer cells |
Paraptosis |
[314] |
Ginsenoside Rh2 |
Ginseng biloba |
colorectal cancer cells |
Paraptosis |
[315] |
Honokiol |
Magnolia officinalis, |
leukemia NB4 cells |
Paraptosis |
[316] |
Hesperidin |
citrus fruits |
hepatocellular carcinoma HepG2 cells |
Paraptosis |
[317] |
Celastrol |
Tripterygium wilfordii |
breast and colon cancer cells |
Paraptosis |
[200, 318] |
Moscatilin |
Dendrobium loddigesii |
squamous cell carcinoma and adenocarcinoma cells |
Mitotic catastrophe |
[328] |
2-deprenyl-rheediaxanthone B |
Metaxya rostrata C. Presl |
colorectal cancer cells |
Mitotic catastrophe |
[329] |
Flavone eupatorin |
Orthosiphon stamineus |
various cancer cells |
Mitotic catastrophe |
[330] |
MMH01 |
Antrodia cinnamomea |
leukemia U937 cells |
Mitotic catastrophe |
[331] |
Ruta |
Ruta graveolens |
brain cancer and HL-60 leukemia cells |
Mitotic catastrophe |
[332] |
Ethanolic extract |
Derris scandens Benth |
colon cancer HT29 cells |
Mitotic catastrophe |
[333] |