Table 3.
Activation of PPAR isotypes by phytocannabinoids.
pCBs | PPARα | PPARβ/δ | PPARγ |
---|---|---|---|
Δ9-THC | Transcriptional activity [104] |
- | Binding assays [106] Transcriptional activity [105] Inhibition by PPARγ antagonists [19, 105] |
CBD | - | - | Binding assays [106] Transcriptional activity [47] Inhibition by PPARγ antagonists[47–49] |
CBG | - | - | Binding assays [106] |
CBC | - | - | Binding assays [106] |
THCV | - | - | NR [18] |
NR: No response