Table 1:

MicroRNAs dysregulated in renal cancer

MicroRNAs	Target genes	Expression	Role	Applications	Ref.
miR-501-5p, miR-23b-3p	TSC1, PTEN, MCU	Up	Cell growth, metastasis	Prognosis	2, 28
miR-21, 106a, 92a	VHL, PTEN, PDC4	Up	Cell growth, migration	Prognosis	19–20, 26–27, 52
miR-210, 155	ISCU1/2, TP53INP1	Up	Metastasis, cell growth	Diagnosis/prognosis	20, 24, 44–45, 49–50
miR-20b, 199a	HIF-α	Down	Anti-angiogenesis	-	25
17–92 cluster	PTEN, E2Fs	Up	Cell growth, invasion	Prognosis	20–22, 24
miR-28-5p	Mad2	Up	Chromosomal instability	-	23
miR-192, 194, 215	ZEB2, MDM2, TYMS	Down	Cell differentiation	Prognosis	29
miR-584	ROCK1	Down	Cell cycle arrest	-	30
miR-135a	cMYC	Down	Cell cycle arrest	-	31
miR-205	SFKs	Down	Cell cycle arrest, apoptosis	-	32
miR-708	Survivin, ZEB2, BMI1	Down	Apoptosis	-	33
miR-1826	CTNNB1, MEK1	Down	Cell cycle arrest, apoptosis	-	34
miR-30d, 185	MTDH, VEGFA	Down	Apoptosis	-	35–36
miR-204	LC3B	Down	Autophagy	-	37–38
miR-30a	BECN1	Down	Inhibition of autophagy	-	39
miR-203, 424	FGF2, PDCD4	Up	Cell proliferation	Diagnosis	41
miR-195, 15b	Raf-1, CCND1	Up	Cell cycle arrest	Diagnosis	42
miR-122-5p	HIF1- α vimentin	Up	Inhibition of cell invasion	Diagnosis	43
miR-378, 451	TOB2, BCL2	Up/down	Apoptosis, cell cycle	Early diagnosis	46
miR-1233	BLCAP, TP53	Up	Inhibition of apoptosis	Early diagnosis	47
miR-193a, 362, 572, 28, 378	MAPK, NFkB, Mad2	Up/down	Cell growth and invasion	Early diagnosis	48
miR-126	VEGFA, BCL2	Down	Cell migration, apoptosis	Prognosis	51–52
miR-125b	E2F3, TP53	Up	Cell growth and migration	Prognosis	53
miR-30c	Snail1/slug, PTP4A1	Down	Inhibition of cell migration	Prognosis	55
miR-200c	CYP1B1, HO-1	Down	Inhibition of cell invasion	Drug response	58–59
miR-942	BRCA pathway	Up	Angiogenesis, metastasis	Drug response	60
miR-141	ZEB2	Down	Cell differentiation	Drug response	61
miR-200	IL-8, CXCL1	Down	Anti-angiogenesis	Therapy	63
miR-99a	mTOR	Down	Cell cycle arrest	Therapy	64