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Lysosomal sequestration of TKIs in several different cell lines
| Drug | Calculated log P | Calculated pKa (strongest basic) | Lysosomal sequestration found in | References |
|---|---|---|---|---|
| Sunitinib | 5.2 | 8.95 | Renal and colon cancer cells | (6) |
| Gefitinib | 3.2 | 7.20 | Hepatocytes | (17) |
| Lapatinib | 5.4 | 7.20 | Hepatocytes | (17) |
| Pazopanib | 3.6 | 5.07 | Renal and colon cancer cells | (18) |
| Erlotinib | 3.2 | 4.59 | Renal and colon cancer cells | (18) |
| Sorafenib | 4.34 | 2.03 | Hepatocellular carcinoma | (19) |
