Figure 1.
KBP‐089 potently reduces appetite, body weight and fat depots in HFD rats. (A) Caloric intake monitored daily initially, and then weekly in high‐fat diet fed rats. Expressed as daily intake per animal. (B) Body weight expressed as percentage from baseline. (C) Food efficiency day 1–56 in rats dosed with KBP‐089 (0.625, 1.25 and 2.5 μg·kg−1). Relative weight of (D) epididymal, (E) inguinal and (F) peritoneal adipose tissue at study end. (n = 10 rats per group in vehicle and KBP‐089 treatment groups; n = 9 rats in pair‐fed group). AT, adipose tissue. Statistical analysis between groups was evaluated by an ordinary one‐way ANOVA with Tukey's multiple comparisons test. *P < 0.05. compared with vehicle, ¤P<0.05 compared with pair‐fed.