Figure 3.

KBP‐089 reduces the accumulation of lipids in both muscle and liver in HFD rats. Oil Red O stained frozen (A) liver sections and (B) gastrocnemius muscle (magnification of ×20 for liver and ×40 for gastrocnemius, nine images per animal; three pictures per depth) in (1) ND rats, (2) vehicle HFD rats, (3) 2.5 μg·kg⁻¹ KBP‐089, (4) pair‐fed to 2.5 μg·kg⁻¹ KBP‐089 and (5) quantification of the results (n = 10 rats per group in vehicle and KBP‐089 treatment groups; n = 9 rats in pair‐fed group). Data are expressed as fold of lean. Statistical analysis between groups was evaluated by a Kruskal–Wallis test with Dunn's multiple comparisons test. *P < 0.05 compared with vehicle, ¤P < 0.05 compared with pair‐fed.