Table 2.
Number (%) of culture-PCR positive samples identified during the study according to challenge outcome and day/time of sample collection. Samples from participants diagnosed with typhoid are further described by day relative to typhoid diagnosis (and antibiotic initiation) in 48-h blocks. nTD, non-typhoid diagnosed; TD, typhoid diagnosed.
| Challenge outcome, n/N (%) |
|||
|---|---|---|---|
| nTD (17 participants) | TD (24 participants) | ALL (41 participants) | |
| Time point after challenge | |||
| Day 0 to Day 3 | 4/62 (6.5) | 5/87 (5.7) | 9/149 (6.0) |
| Day 3 onwards | 11/203 (5.4) | 37/332 (11.1) | 48/535 (9.0) |
| Total | 15/265 (5.7) | 42/411 (10.2) | 57/684 (8.3) |
| Time relative to TD | |||
| >−72 h | – | 2/57 (3.5) | – |
| −72 to −24 h | – | 18/44 (40.9) | – |
| −24 to +24 h | – | 15/39 (38.4) | – |
| +24 to +72 h | – | 0/83 (0) | – |
| >72 h | – | 2/71 (2.8) | – |