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Disease activity strongly correlates with LL37 and IL6 concentrations. Healthy, inactive and active BD patient EVs were analysed for LL37 association levels and subsequent IL6 production by healthy PBMCs. The correlation plot was prepared from these two independent data to determine the correlation coefficient between disease states IL6 secretion and LL37 levels. R2 = coefficient of correlation (n = 12 for all sample plasmas).
