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. Author manuscript; available in PMC: 2017 Mar 28.
Published in final edited form as: Leukemia. 2016 Sep 28;31(3):678–687. doi: 10.1038/leu.2016.260

Figure 3. Treatment with BET bromodomain inhibitors induces differentiation and apoptosis in sAML cells.

Figure 3

A-B. HEL92.1.7 and SET-2 cells were treated with the indicated concentrations of JQ1 or OTX-015 for 48 hours. The % apoptotic cells were determined by flow cytometry. Columns, mean apoptosis from three experiments; Bars, standard error of the mean. C. HEL92.1.7 cells were treated with 100 nM of JQ1 for 96 hours. At the end of treatment, the % CD11b and CD14-positive cells in HEL92.1.7 cells were determined. *** indicates significantly increased CD11b or CD14 expression levels in JQ1 treated cells compared to control cells (p<0.005).