Table 2.
Distribution of genotype frequencies of the susceptibility loci and their associations with GC risk
| Genotype | Genetic model | Controls n (%) | GC cases n (%) | OR (95% CI)a | P |
|---|---|---|---|---|---|
| PLCE1 rs2274223 | |||||
| AA | Codominant | 317 (65.0) | 291 (59.3) | 1 | |
| AG | 153 (31.3) | 174 (35.4) | 1.40 (1.03–1.91) | 0.033 | |
| GG | 18 (3.7) | 26 (5.3) | 2.18 (1.07–4.45) | 0.032 | |
| AA | Dominant | 317 (65.0) | 291 (59.3) | 1 | |
| AG+GG | 171 (35.0) | 200 (40.7) | 1.48 (1.09–1.99) | 0.011 | |
| G allele | Additive | 1.43 (1.11–1.84) | 0.005 | ||
| PSCA rs2294008 | |||||
| CC | Codominant | 268 (54.9) | 215 (44.3) | 1 | |
| CT | 173 (35.5) | 225 (46.4) | 1.50 (1.10–2.04) | 0.01 | |
| TT | 47 (9.6) | 45 (9.3) | 1.10 (0.66–1.83) | 0.725 | |
| CC | Dominant | 268 (54.9) | 215 (44.3) | 1 | |
| CT+TT | 220 (45.1) | 270 (55.7) | 1.41 (1.05–1.89) | 0.021 | |
| T allele | Additive | 1.20 (0.96–1.49) | 0.112 | ||
| PSCA rs2976392 | |||||
| GG | Codominant | 268 (54.9) | 213 (44.3) | 1 | |
| AG | 173 (35.5) | 223 (46.4) | 1.49 (1.10–2.04) | 0.011 | |
| AA | 47 (9.6) | 45 (9.3) | 1.11 (0.66–1.85) | 0.699 | |
| GG | Dominant | 268 (54.9) | 213 (44.3) | 1 | |
| AA+AG | 220 (45.1) | 268 (55.7) | 1.41 (1.05–1.89) | 0.021 | |
| A allele | Additive | 1.20 (0.96–1.50) | 0.109 | ||
| MUC1 rs4072037 | |||||
| AA | Codominant | 318 (65.2) | 371 (77.3) | 1 | |
| AG | 152 (31.1) | 92 (19.2) | 0.54 (0.38–0.76) | <0.001 | |
| GG | 18 (3.7) | 17 (3.5) | 1.01 (0.48–2.15) | 0.974 | |
| AA | Dominant | 318 (65.2) | 371 (77.3) | 1 | |
| AG+GG | 170 (34.8) | 109 (22.7) | 0.59 (0.42–0.81) | 0.001 | |
| G allele | Additive | 0.71 (0.54–0.93) | <0.001 | ||
| ZBTB20 rs9841504 | |||||
| CC | Codominant | 349 (71.5) | 368 (75.6) | 1 | |
| CG | 124 (25.4) | 95 (19.5) | 0.65 (0.45–0.92) | 0.015 | |
| GG | 15 (3.1) | 24 (4.9) | 1.85 (0.86–3.97) | 0.114 | |
| CC | Dominant | 349 (71.5) | 368 (75.6) | 1 | |
| CG+GG | 139 (28.5) | 119 (24.4) | 0.76 (0.54–1.05) | 0.094 | |
| G allele | Additive | 0.91 (0.70–1.19) | 0.486 | ||
| SLC52A3 rs13042395 | |||||
| CC | Codominant | 180 (36.8) | 238 (48.7) | 1 | |
| CT | 247 (50.5) | 211 (43.1) | 0.77 (0.56–1.04) | 0.088 | |
| TT | 62 (12.7) | 40 (8.2) | 0.46 (0.27–0.76) | 0.003 | |
| CC | Dominant | 180 (36.8) | 238 (48.7) | 1 | |
| CT+TT | 309 (63.2) | 251 (51.3) | 0.70 (0.52–0.93) | 0.016 | |
| T allele | Additive | 0.71 (0.56–0.88) | 0.002 | ||
| PRKAA1 rs13361707 | |||||
| CC | Codominant | 98 (20.1) | 172 (36.4) | 1 | |
| CT | 246 (50.5) | 213 (45.0) | 0.48 (0.34–0.68) | <0.001 | |
| TT | 143 (29.4) | 88 (18.6) | 0.35 (0.23–0.54) | <0.001 | |
| CC | Dominant | 98 (20.1) | 172 (36.4) | 1 | |
| CT+TT | 389 (79.9) | 301 (63.6) | 0.43 (0.31–0.61) | <0.001 | |
| T allele | Additive | 0.59 (0.48–0.73) | <0.001 | ||
| Risk genotype | |||||
| 0–1 | 156 (32.0) | 74 (15.7) | 1 | ||
| 2–3 | 294 (60.4) | 297 (62.9) | 2.13 (1.55–2.93) | <0.001 | |
| 4–5 | 37 (7.6) | 101 (21.4) | 5.76 (3.61–9.18) | <0.001 | |
a
Adjusted for age, sex, smoking, drinking status, and Helicobacter pylori infection status in logistic models.