Table 3.
Association between each of the susceptibility loci and risk of GC, stratified by Helicobacter pylori infection
| H. pylori infection | Genotype | Controls n (%) | Cases n (%) | OR (95% CI)a | P |
|---|---|---|---|---|---|
| PLCE1 rs2274223 | |||||
| – | AA | 134 (64.7) | 34 (60.7) | 1.00 | |
| – | AG+GG | 73 (35.3) | 22 (39.3) | 1.59 (0.82–3.09) | 0.174 |
| I | AA | 111 (68.1) | 186 (57.6) | 1.00 | |
| I | AG+GG | 52 (31.9) | 137 (42.4) | 1.59 (1.04–2.43) | 0.032 |
| II | AA | 72 (61.5) | 61 (60.4) | 1.00 | |
| II | AG+GG | 45 (38.5) | 40 (39.6) | 1.34 (0.74–2.43) | 0.328 |
| PSCA rs2294008 | |||||
| – | CC | 109 (52.7) | 33 (60.0) | 1.00 | |
| – | CT+TT | 98 (47.3) | 22 (40.0) | 0.57 (0.28–1.15) | 0.116 |
| I | CC | 93 (57.1) | 133 (41.7) | 1.00 | |
| I | CT+TT | 70 (42.9) | 186 (58.3) | 1.93 (1.28–2.90) | 0.002 |
| II | CC | 65 (55.6) | 43 (43.0) | 1.00 | |
| II | CT+TT | 52 (44.4) | 57 (57.0) | 1.45 (0.81–2.60) | 0.206 |
| PSCA rs2976392 | |||||
| – | GG | 109 (52.7) | 33 (60.0) | 1.00 | |
| – | AA+AG | 98 (47.3) | 22 (40.0) | 0.57 (0.28–1.15) | 0.116 |
| I | GG | 93 (57.1) | 132 (41.8) | 1.00 | |
| I | AA+AG | 70 (42.9) | 184 (58.2) | 1.92 (1.27–2.89) | 0.002 |
| II | GG | 65 (55.6) | 42 (42.4) | 1.00 | |
| II | AA+AG | 52 (44.4) | 57 (57.6) | 1.50 (0.84–2.69) | 0.173 |
| MUC1 rs4072037 | |||||
| – | AA | 136 (65.7) | 45 (81.8) | 1.00 | |
| – | AG+GG | 71 (34.3) | 10 (18.2) | 0.44 (0.19–1.01) | 0.053 |
| I | AA | 101 (62.0) | 237 (75.0) | 1.00 | |
| I | AG+GG | 62 (38.0) | 79 (25.0) | 0.64 (0.42–0.99) | 0.046 |
| II | AA | 80 (68.4) | 80 (81.6) | 1.00 | |
| II | AG+GG | 37 (31.6) | 18 (18.4) | 0.47 (0.23–0.96) | 0.037 |
| ZBTB20 rs9841504 | |||||
| – | CC | 151 (72.9) | 45 (80.4) | 1.00 | |
| – | CG+GG | 56 (27.1) | 11 (19.6) | 0.57 (0.25–1.33) | 0.192 |
| I | CC | 115 (70.6) | 238 (74.4) | 1.00 | |
| I | CG+GG | 48 (29.4) | 82 (25.6) | 0.83 (0.53–1.30) | 0.419 |
| II | CC | 83 (70.9) | 76 (76.0) | 1.00 | |
| II | CG+GG | 34 (29.1) | 24 (24.0) | 0.74 (0.38–1.43) | 0.371 |
| SLC52A3 rs13042395 | |||||
| – | CC | 72 (34.6) | 25 (44.6) | 1.00 | |
| – | CT+TT | 136 (65.4) | 31 (55.4) | 0.76 (0.38–1.49) | 0.417 |
| I | CC | 67 (41.1) | 158 (49.2) | 1.00 | |
| I | CT+TT | 96 (58.9) | 163 (50.8) | 0.74 (0.49–1.11) | 0.148 |
| II | CC | 40 (34.2) | 46 (45.5) | 1.00 | |
| II | CT+TT | 77 (65.8) | 55 (54.5) | 0.64 (0.35–1.15) | 0.137 |
| PRKAA1 rs13361707 | |||||
| – | CC | 44 (21.4) | 21 (38.2) | 1.00 | |
| – | CT+TT | 162 (78.6) | 34 (61.8) | 0.50 (0.24–1.04) | 0.064 |
| I | CC | 34 (20.9) | 116 (37.3) | 1.00 | |
| I | CT+TT | 129 (79.1) | 195 (62.7) | 0.46 (0.29–0.73) | 0.001 |
| II | CC | 20 (17.1) | 32 (33.3) | 1.00 | |
| II | CT+TT | 97 (82.9) | 64 (66.7) | 0.39 (0.20–0.78) | 0.007 |
a
Adjusted for age, sex, smoking, and alcohol drinking status in logistic models.