Table 4.
Joint effects of Helicobacter pylori seropositivity and genetic variants on risk of GC
| Genotype | H. pylori infection | Controls n (%) | Cases n (%) | OR (95% CI)a | P |
|---|---|---|---|---|---|
| PLCE1 rs2274223 | |||||
| AA | − | 134 (27.5) | 34 (7.1) | 1.00 | |
| AA | + | 183 (37.6) | 247 (51.4) | 6.07 (3.72–9.88) | <0.002 |
| AG/GG | − | 73 (15.0) | 22 (4.6) | 1.56 (0.80–3.02) | 0.192 |
| AG/GG | + | 97 (19.9) | 177 (36.9) | 8.82 (5.28–14.74) | <0.001 |
| Multiplicative interaction | 0.94 (0.45–1.97) | 0.861 | |||
| Additive interaction: SI | 1.39 (0.93–2.12) | ||||
| PSCA rs2294008 | |||||
| CC | − | 109 (22.4) | 33 (7.0) | 1.00 | |
| CC | + | 158 (32.4) | 176 (37.1) | 3.56 (2.20–5.75) | <0.001 |
| CT/TT | − | 98 (20.1) | 22 (4.6) | 0.57 (0.29–1.14) | 0.110 |
| CT/TT | + | 122 (25.1) | 243 (51.3) | 6.20 (3.83–10.05) | <0.001 |
| Multiplicative interaction | 3.05 (1.43–6.53) | 0.004 | |||
| Additive interaction: SI | 2.45 (1.55–5.52) | ||||
| PSCA rs2976392 | |||||
| GG | − | 109 (22.4) | 33 (7.0) | 1.00 | |
| GG | + | 158 (32.4) | 174 (37.0) | 3.51 (2.17–5.69) | <0.001 |
| AG/AA | − | 98 (20.1) | 22 (4.7) | 0.57 (0.29–1.13) | 0.110 |
| AG/AA | + | 122 (25.1) | 241 (51.3) | 6.14 (3.79–9.95) | <0.001 |
| Multiplicative interaction | 3.06 (1.43–6.54) | 0.004 | |||
| Additive interaction: SI | 2.47 (1.43–5.61) | ||||
| MUC1 rs4072037 | |||||
| AG/GG | − | 71 (14.6) | 10 (2.1) | 1.00 | |
| AG/GG | + | 99 (20.3) | 97 (20.7) | 7.49 (3.38–16.63) | <0.001 |
| AA | − | 136 (27.9) | 45 (9.6) | 2.19 (0.95–5.02) | 0.065 |
| AA | + | 181 (37.2) | 317 (67.6) | 12.19 (5.67–26.21) | <0.001 |
| Multiplicative interaction | 0.74 (0.30–1.83) | 0.520 | |||
| Additive interaction: SI | 1.46 (0.97–2.33) | ||||
| ZBTB20 rs9841504 | |||||
| CG/GG | − | 56 (11.5) | 11 (2.3) | 1.00 | |
| CG/GG | + | 82 (16.8) | 106 (22.3) | 7.97 (3.54–17.93) | <0.001 |
| CC | − | 151 (31.0) | 45 (9.4) | 1.84 (0.80–4.23) | 0.154 |
| CC | + | 198 (40.7) | 314 (66.0) | 9.87 (4.55–21.43) | <0.001 |
| Multiplicative interaction | 0.68 (0.27–1.68) | 0.397 | |||
| Additive interaction: SI | 1.14 (0.79–1.76) | ||||
| SLC52A3 rs13042395 | |||||
| CT/TT | − | 136 (27.9) | 31 (6.5) | 1.00 | |
| CT/TT | + | 173 (35.4) | 218 (45.6) | 5.67 (3.51–9.15) | <0.001 |
| CC | − | 72 (14.8) | 25 (5.2) | 1.32 (0.67–2.60) | 0.423 |
| CC | + | 107 (21.9) | 204 (42.7) | 8.32 (5.08–13.65) | <0.001 |
| Multiplicative interaction | 1.11 (0.52–2.36) | 0.781 | |||
| Additive interaction: SI | 1.47 (0.99–2.24) | ||||
| PRKAA1 rs13361707 | |||||
| CT/TT | − | 162 (33.3) | 34 (7.4) | 1.00 | |
| CT/TT | + | 226 (46.5) | 259 (56.1) | 5.47 (3.51–8.55) | <0.001 |
| CC | − | 44 (9.1) | 21 (4.5) | 2.00 (0.97–4.12) | 0.061 |
| CC | + | 54 (11.1) | 148 (32.0) | 13.11 (7.80–22.04) | <0.001 |
| Multiplicative interaction | 1.20 (0.53–2.71) | 0.663 | |||
| Additive interaction: SI | 2.21 (1.39–3.69) | ||||
a
Adjusted for age, sex, smoking, and drinking status in logistic models.