Table 5.
Joint effects of alcohol drinking status and genetic variants on risk of GC
| Genotype | Alcohol drinking | Controls n (%) | Cases n (%) | OR (95% CI)a | P |
|---|---|---|---|---|---|
| PLCE1 rs2274223 | |||||
| AA | − | 240 (49.2) | 134 (32.5) | 1.00 | |
| AA | + | 77 (15.8) | 101 (24.5) | 2.83 (1.81–4.42) | <0.001 |
| AG/GG | − | 130 (26.6) | 95 (23.1) | 1.35 (0.94–1.95) | 0.106 |
| AG/GG | + | 41 (8.4) | 82 (19.9) | 4.96 (2.98–8.26) | <0.001 |
| Multiplicative interaction | 1.30 (0.69–2.45) | 0.421 | |||
| Additive interaction: SI | 1.82 (0.89–3.87) | ||||
| PSCA rs2294008 | |||||
| CC | − | 207 (42.4) | 107 (26.3) | 1.00 | |
| CC | + | 61 (12.5) | 77 (18.9) | 2.86 (1.74–4.70) | <0.001 |
| CT/TT | − | 163 (33.4) | 119 (29.2) | 1.33 (0.93–1.89) | 0.122 |
| CT/TT | + | 57 (11.7) | 104 (25.6) | 4.57 (2.82–7.41) | <0.001 |
| Multiplicative interaction | 1.21 (0.65–2.24) | 0.555 | |||
| Additive interaction: SI | 1.63 (0.83–3.70) | ||||
| PSCA rs2976392 | |||||
| GG | − | 207 (42.4) | 106 (26.3) | 1.00 | |
| GG | + | 61 (12.5) | 76 (18.8) | 2.85 (1.74–4.69) | <0.001 |
| AG/AA | − | 163 (33.4) | 118 (29.3) | 1.32 (0.93–1.89) | 0.125 |
| AG/AA | + | 57 (11.7) | 103 (25.6) | 4.57 (2.82–7.41) | <0.001 |
| Multiplicative interaction | 1.21 (0.65–2.26) | 0.545 | |||
| Additive interaction: SI | 1.64 (0.83–3.83) | ||||
| MUC1 rs4072037 | |||||
| AG/GG | − | 130 (26.6) | 55 (13.7) | 1.00 | |
| AG/GG | + | 40 (8.2) | 40 (10.0) | 2.95 (1.59–5.49) | 0.001 |
| AA | − | 240 (49.2) | 169 (42.0) | 1.67 (1.12–2.49) | 0.011 |
| AA | + | 78 (16.0) | 138 (34.3) | 5.26 (3.21–8.63) | <0.001 |
| Multiplicative interaction | 1.07 (0.54–2.12) | 0.857 | |||
| Additive interaction: SI | 1.62 (0.88–3.66) | ||||
| ZBTB20 rs9841504 | |||||
| CG/GG | − | 101 (20.7) | 51 (12.5) | 1.00 | |
| CG/GG | + | 38 (7.8) | 51 (12.5) | 3.16 (1.72–5.79) | <0.001 |
| CC | − | 269 (55.1) | 177 (43.4) | 1.31 (0.87–1.98) | 0.194 |
| CC | + | 80 (16.4) | 129 (31.6) | 4.23 (2.52–7.09) | <0.001 |
| Multiplicative interaction | 1.02 (0.52–2.02) | 0.955 | |||
| Additive interaction: SI | 1.31 (0.61–3.36) | ||||
| SLC52A3 rs13042395 | |||||
| CT/TT | − | 231 (47.2) | 124 (30.3) | 1.00 | |
| CT/TT | + | 78 (16.0) | 86 (21.0) | 2.63 (1.67–4.14) | <0.001 |
| CC | − | 139 (28.4) | 104 (25.4) | 1.25 (0.87–1.80) | 0.221 |
| CC | + | 41 (8.4) | 95 (23.3) | 5.01 (3.02–8.31) | <0.001 |
| Multiplicative interaction | 1.52 (0.81–2.86) | 0.192b | |||
| Additive interaction: SI | 2.13 (1.04–5.73) | ||||
| PRKAA1 rs13361707 | |||||
| CT/TT | − | 296 (60.8) | 141 (35.5) | 1.00 | |
| CT/TT | + | 93 (19.1) | 113 (28.5) | 3.33 (2.19–5.10) | <0.001 |
| CC | − | 74 (15.2) | 81 (20.4) | 2.46 (1.64–3.68) | <0.001 |
| CC | + | 24 (4.9) | 62 (15.6) | 6.67 (3.70–12.03) | <0.001 |
| Multiplicative interaction | 0.82 (0.40–1.67) | 0.577 | |||
| Additive interaction: SI | 1.50 (0.73–3.00) | ||||
a
Adjusted for age, sex, smoking status, and Helicobacter pylori infection status in logistic regression models.