Table 6.
Association of the seven SNPs with risk of severe IM/dysplasia
| Genotype | Genetic model | Controls n (%) | Severe IM/Dysplasia n (%) | OR (95% CI)a | P a |
|---|---|---|---|---|---|
| PLCE1 rs2274223 | |||||
| AA | Codominant | 317 (65.0) | 197 (70.9) | 1 | |
| AG | 153 (31.3) | 74 (26.6) | 0.78 (0.55–1.11) | 0.171 | |
| GG | 18 (3.7) | 7 (2.5) | 0.67 (0.26–1.71) | 0.400 | |
| AA | Dominant | 317 (65.0) | 197 (70.9) | 1 | |
| AG+GG | 171 (35.0) | 81 (29.1) | 0.77 (0.55–1.08) | 0.133 | |
| G allele | Additive | 0.80 (0.59–1.07) | 0.127 | ||
| PSCA rs2294008 | |||||
| CC | Codominant | 268 (54.9) | 146 (52.5) | 1 | |
| CT | 173 (35.5) | 115 (41.4) | 1.23 (0.89–1.71) | 0.212 | |
| TT | 47 (9.6) | 17 (6.1) | 0.74 (0.40–1.37) | 0.333 | |
| CC | Dominant | 268 (54.9) | 146 (52.5) | 1 | |
| CT+TT | 220 (45.1) | 132 (47.5) | 1.13 (0.83–1.54) | 0.440 | |
| T allele | Additive | 1.01 (0.79–1.28) | 0.955 | ||
| PSCA rs2976392 | |||||
| GG | Codominant | 268 (54.9) | 146 (52.7) | 1 | |
| AG | 173 (35.5) | 114 (41.2) | 1.21 (0.87–1.69) | 0.247 | |
| AA | 47 (9.6) | 17 (6.1) | 0.74 (0.40–1.36) | 0.328 | |
| GG | Dominant | 268 (54.9) | 146 (52.7) | 1 | |
| AA+AG | 220 (45.1) | 131 (47.3) | 1.12 (0.82–1.53) | 0.492 | |
| A allele | Additive | 1.00 (0.78–1.27) | 0.996 | ||
| MUC1 rs4072037 | |||||
| AA | Codominant | 318 (65.2) | 207 (74.5) | 1 | |
| AG | 152 (31.1) | 63 (22.6) | 0.64 (0.45–0.92) | 0.016 | |
| GG | 18 (3.7) | 8 (2.9) | 0.70 (0.28–1.76) | 0.441 | |
| AA | Dominant | 318 (65.2) | 207 (74.5) | 1 | |
| AG+GG | 170 (34.8) | 71 (25.5) | 0.65 (0.46–0.92) | 0.014 | |
| G allele | Additive | 0.70 (0.52–0.95) | 0.022 | ||
| ZBTB20 rs9841504 | |||||
| CC | Codominant | 349 (71.5) | 214 (77.3) | 1 | |
| CG | 124 (25.4) | 48 (17.3) | 0.59 (0.40–0.87) | 0.008 | |
| GG | 15 (3.1) | 15 (5.4) | 1.51 (0.69–3.29) | 0.298 | |
| CC | Dominant | 349 (71.5) | 214 (77.3) | 1 | |
| CG+GG | 139 (28.5) | 63 (22.7) | 0.69 (0.48–0.99) | 0.043 | |
| G allele | Additive | 0.84 (0.63–1.13) | 0.245 | ||
| SLC52A3 rs13042395 | |||||
| CC | Codominant | 180 (36.8) | 117 (42.1) | 1 | |
| CT | 247 (50.5) | 134 (48.2) | 0.89 (0.64–1.23) | 0.476 | |
| TT | 62 (12.7) | 27 (9.7) | 0.58 (0.34–0.99) | 0.045 | |
| CC | Dominant | 180 (36.8) | 117 (42.1) | 1 | |
| CT+TT | 309 (63.2) | 161 (57.9) | 0.82 (0.60–1.12) | 0.215 | |
| T allele | Additive | 0.80 (0.63–1.02) | 0.067 | ||
| PRKAA1 rs13361707 | |||||
| CC | Codominant | 98 (20.1) | 71 (25.8) | 1 | |
| CT | 246 (50.5) | 139 (50.6) | 0.71 (0.48–1.04) | 0.081 | |
| TT | 143 (29.4) | 65 (23.6) | 0.62 (0.40–0.97) | 0.037 | |
| CC | Dominant | 98 (20.1) | 71 (25.8) | 1 | |
| CT+TT | 389 (79.9) | 204 (74.2) | 0.68 (0.47–0.98) | 0.038 | |
| T allele | Additive | 0.79 (0.63–0.99) | 0.040 | ||
a
Adjusted for age, sex, smoking, and alcohol drinking status and Helicobacter pylori infection status in logistic regression models.