Figure 4.

Hierarchical clustering of the differentially expressed miRNAs induced by dioscin in ASPC‐1 cells. Each row represented an individual miRNA, and each column represented a sample. The dendrogram at the top of the image displayed the similarity of expression between these samples at the same stage. The red colour indicated high relative expression level, and green indicated low relative expression level. Fold changes >2.0 and P‐values <0.05 were considered significant (n = 5). The miRNA marked in red to the right of the hierarchical clustering was selected for verification. (A) Up‐regulated miRNAs in ASPC‐1 cells identified by microarrays. (B) Down‐regulated miRNAs in ASPC‐1 cells identified by microarrays.