Table 1.
HPV diagnosis and its association with different clinicoepidemiological and pathological characteristics of the oral cancer cases included in the study
| Sample/case Characteristics | Overall (n = 135) | HPV+ve (n = 31) | HPV‐ve (n = 104) | P Value* |
|---|---|---|---|---|
| Age in Years | 51.8 (±12.9) | 46.2 (±13.3) | 53.3 (±12.3) | 0.010 1 |
| Male/female ratio | 110/25 (4.4:1) | 27/4 (6.75:1) | 83/21 (3.9:1) | |
| Marital status (%) | ||||
| Single | 13 (9.6) | 6 (19.3) | 7 (6.7) | 0.038 |
| Married | 122 (90.3) | 25 (71.4) | 97 (93.2) | 0.001 |
| Habits (%) | ||||
| Smoking only | 14 (10.3) | 5 (16.1) | 9 (8.6) | 0.230 |
| Chewing only | 19 (14.0) | 5 (16.1) | 14 (13.4) | 0.704 |
| Alcohol only | 3 (2.2) | 1 (3.2) | 2 (1.9) | 0.433 |
| Smoking + chewing | 13 (9.6) | 5 (16.1) | 8 (7.6) | 0.159 |
| Smoking + alcohol | 14 (10.3) | 2 (6.4) | 11 (10.5) | 0.496 |
| Chewing + alcohol | 3 (2.2) | 2 (6.4) | 1 (0.9) | 0.066 |
| All | 37 (27.4) | 6 (19.3) | 31 (29.8) | 0.252 |
| Chewing (± Any habit) | 72 (53.3) | 13 (41.9) | 40 (38.4) | 0.726 |
| Smoking (± Any habit) | 78 (57.7) | 13 (41.9) | 50 (48.0) | 0.551 |
| Alcohol (± Any habit) | 57 (42.2) | 10 (32.2) | 43 (41.3) | 0.364 |
| Tumor site (%) | ||||
| Oral cavity | 102 (75) | 18 (58) | 84 (80.7) | 0.011 |
| Buccal mucosa | 39 (28.8) | 7 (22.5) | 32 (30.7) | 0.377 |
| Alveolar/gingival | 31 (22.9) | 6 (19.3) | 25 (24) | 0.585 |
| Vestibule | 4 (6.5) | 1 (3.2) | 3 (2.8) | 0.907 |
| Retromolar space | 6 (9.8) | 1 (3.2) | 5 (4.8) | 0.704 |
| Floor of mouth | 4 (6.5) | 1 (3.2) | 3 (2.8) | 0.907 |
| Tongue | 18 (13.3) | 2 (6.4) | 16 (15.3) | 0.201 |
| Oropharyngeal | 33 (25) | 13 (41.9) | 20 (19.2) | 0.010 |
| Base of tongue | 17 (12.5) | 9 (29) | 8 (7.6) | 0.001 |
| Tonsil | 12 (8.8) | 4 (12.9) | 8 (7.6) | 0.362 |
| Oropharynx | 4 (6.5) | Nil | 4 (3.8) | 0.272 |
| Histopathology (%) | ||||
| WDSCC | 74 (54.8) | 13 (41.9) | 61 (58.6) | 0.103 |
| MDSCC | 50 (37.0) | 14 (45.1) | 36 (34.6) | 0.289 |
| PDSCC | 11 (8.1) | 4 (12.9) | 7 (6.7) | 0.269 |
| TNM (%) | ||||
| Stage I | 20 (14.8) | 5 (16.1) | 15 (14.4) | 0.815 |
| Stage II | 5 (3.7) | Nil | 5 (4.8) | 0.216 |
| Stage III | 37 (27.4) | 6 (19.3) | 31 (29.8) | 0.252 |
| Stage IV | 73 (54.0) | 20 (64.5) | 53 (50.9) | 0.184 |
1Mann–Whitney test was used for comparison of mean age and chi‐square test was used for parametric analysis between HPV+ve and HPV‐ve populaions. *Bold value defines the statistically significant relation.