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. 2016 Nov 18;21(4):746–757. doi: 10.1111/jcmm.13017

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© 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of L2H21 on LPS‐induced ALI. L2H21 (20 mg/kg) was consecutively administrated to C57BL/6 mice for 7 days by intragastric administration, and 6 hrs after intratracheal stimulation of LPS (5 mg/kg), the right lung and trachea was isolated. (A) The lung histological changes were assessed by haematoxylin and eosin staining. (B) The histogram of lung injury scores based on A. (C) The lung Wet/Dry weight ratio. (D) Protein concentration in BALF. The values presented are the means ± S.E.M. *P < 0.05 and **P < 0.01 versus LPS group.