Table 3.
Risk of dying from all causes among women with TNBC according to clinical characteristics of the tumor and treatment
| Univariate | Multiadjusted modela | |
|---|---|---|
| HR (95% CI) | HR (95% CI) | |
| Age category (years) | ||
| <50 | 1 | 1 |
| 50–69 | 0.89 (0.43–1.82) | 0.90 (0.41–1.99) |
| ≥70 | 1.74 (0.78–3.88) | 2.00 (1.00–4.88) |
| Birthplace | ||
| Europe + North America | 1 | 1 |
| Other | 2.22 (1.13–4.35)* | 2.40 (1.17–4.95)* |
| Familial history | ||
| Without | 1 | |
| Moderate | 0.95 (0.46–1.94) | |
| High | 0.53 (0.13–2.21) | |
| Unknown | – | |
| Method of detection | ||
| Screening | 1 | 1 |
| Self‐examination | 3.24 (1.13–9.31)* | 2.49 (0.83–7.48) |
| Clinical exam | 3.43 (0.77–15.3) | 3.05 (0.65–14.4) |
| Fortuitous | 4.06 (1.21–13.6)* | 2.45 (0.68–8.84) |
| Unknown | – | – |
| Sector of care | ||
| Private | 1 | |
| Public | 1.18 (0.63–2.19) | |
| Genetic counseling consultation | ||
| No | 1 | |
| Yes | 0.49 (0.18–1.32) | |
| Histology | ||
| Ductal | 1 | |
| Lobular | 2.17 (0.67–7.05) | |
| Other | 0.50 (0.12–2.10) | |
| Multifocality | ||
| No | 1 | |
| Yes | 1.64 (0.81–3.36) | |
| In situ component | ||
| No | 1 | |
| Yes, ductal | 1.88 (0.88–4.03) | |
| Yes, other | 2.46 (0.54–11.3) | |
| Unknown | 2.90 (1.18–7.14) | |
| Lymph nodes status | ||
| Positive | 1 | 1 |
| Negative | 0.39 (0.21–0.73)** | 0.47 (0.24–0.95)* |
| Tumor size (cm) | ||
| <2 | 1 | 1 |
| <5 | 1.90 (0.81–4.45) | 1.55 (0.74–3.76) |
| ≥5 | 3.85 (1.18–12.5)* | 2.51 (0.69–9.20) |
| Unknown | 3.08 (1.35–7.03)** | 1.76 (0.72–4.34) |
| Stage | ||
| I | 1 | |
| II | 1.97 (0.78–5.00) | |
| III | 5.90 (2.34–14.9)*** | |
| Differentiation | ||
| Well/Moderately | 1 | 1 |
| Poorly | 1.08 (0.53–2.17) | 0.96 (0.45–2.06) |
| Unknown | 4.93 (1.08–22.4)* | 5.00 (0.92–27.0) |
| Chemotherapy | ||
| Yes | 1 | |
| No | 1.29 (0.62–2.70) | |
| Unknown | – | |
HR, hazard ratio; CI, confidence interval.
P‐value *<0.05; **<0.01; ***<0.001.
a
Model adjusted on: age, place of birth, method of detection, axillary lymph node status, pathological tumor size, and differentiation.