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. 2017 Jan 30;7(3):1049–1060. doi: 10.1534/g3.117.039065

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Copyright © 2017 Shu and Deng

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yki uses Sd to regulate CycE, and inhibits endoreplication. (A–A’’) Sd and Hth expression patterns in the wing disc were examined using an Sd antibody [(A), shown in red and a Hth:YFP protein trap strain (A’), shown in green]. Signal heat maps are inset accordingly. The scale bar is 50 cm. (B–B’’) Effect of knocking down Sd in Yki-overexpressing cells was examined using a CycE reporter CycE-lacZ. The scale bar is 50 cm. (C–F’’) The effects of Sd on the nuclear size were examined through genetic experiments, including Fzr/Sd, Fzr/Sd-RNAi, Fzr/yki^M123/Sd, and Fzr/yki^M123/Sd-RNAi. The scale bar is 20 cm. (G) Quantifications of NEIs of Sd genetic studies in the wing pouch. Significant differences were observed between Fzr/yki^M123 and Fzr/yki^M123/Sd, and Fzr/yki^M123 and Fzr/yki^M123/Sd-RNAi [n(Fzr) = 62, n(Fzr/yki^M123) = 31, n(Fzr/Sd) = 36, n(Fzr/Sd-RNAi) = 93, n(Fzr/yki^M123/Sd) = 96, and n(Fzr/yki^M123/Sd-RNAi) = 68; error bars are SE values]. CycE, Cyclin E; Fzr, Fizzy-related; GFP, green fluorescent protein; Hth, Homeothorax; NEI, nuclear enlargement index; RNAi, RNA interference; Sd, Scalloped; Yki, Yorkie.