Table 5.

Univariable and multivariable competing risk models

	Univariable		Multivariable
Local recurrence	HR (95% CI)	p-value	HR (95% CI)	p-value
Age, years	0.96 (0.95 – 0.98)	<0.0001	0.98 (0.96 – 0.99)	0.020
Tumor size	1.13 (1.00 – 1.27)	0.045	0.99 (0.78 – 1.25)	0.93
Clinical stage
T1	1.00 (ref)		---	---
T2	1.68 (1.05 – 2.69)	0.031
LVI
absent	1.00 (ref)		1.00 (ref)
present	1.60 (0.98 – 2.62)	0.062	1.33 (0.74 – 2.38)	0.34
Tumor Grade
I	1.00 (ref)		1.00 (ref)
II	1.77 (1.06 – 2.94)	0.028	1.24 (0.70 – 2.16)	0.45
III	3.25 (1.96 – 5.39)	<0.0001	1.59 (0.81 – 3.12)	0.18
HR status
negative	1.00 (ref)		1.00 (ref)
positive	0.32 (0.22 – 0.46)	<0.0001	0.35 (0.20 – 0.62)	0.0003
Chemotherapy
no	1.00 (ref)		1.00 (ref)
yes	1.43 (0.99 – 2.05)	0.054	0.58 (0.35 – 0.95)	0.030
Hormonal therapy
no	1.00 (ref)		---	---
yes	0.45 (0.31 – 0.65)	<0.0001
Radiation therapy
no	1.00 (ref)		1.00 (ref)
yes	0.89 (0.45 – 1.75)	0.73	0.78 (0.38 – 1.62)	0.51
Local-Regional recurrence
Age, years	0.97 (0.95 – 0.98)	<0.0001	0.98 (0.96 – 1.00)	0.049
Tumor size	1.14 (1.02 – 1.27)	0.019	1.01 (0.82 – 1.25)	0.91
Clinical stage
T1	1.00 (ref)		---	---
T2	1.87 (1.29 – 2.88)	0.005
LVI
absent	1.00 (ref)		1.00 (ref)
present	1.80 (1.14 – 2.83)	0.011	1.49 (0.87 – 2.55)	0.14
Tumor Grade
I	1.00 (ref)		1.00 (ref)
II	1.66 (1.02 – 2.69)	0.040	1.12 (0.66 – 1.91)	0.68
III	3.21 (1.99 – 5.16)	<0.0001	1.66 (0.88 – 3.13)	0.11
HR status
negative	1.00 (ref)		1.00 (ref)
positive	0.33 (0.23 – 0.48)	<0.0001	0.42 (0.24 – 0.71)	0.0014
Chemotherapy
no	1.00 (ref)		1.00 (ref)
yes	1.42 (1.00 – 2.01)	0.049	0.60 (0.37 – 0.97)	0.0039
Hormonal therapy
no	1.00 (ref)		---	---
yes	0.45 (0.32 – 0.64)	<0.0001
Radiation therapy
no	1.00 (ref)		1.00 (ref)
yes	0.87 (0.45 – 1.65)	0.66	0.85 (0.41 – 1.76)	0.67
Distant recurrence	HR (95% CI)	p-value	HR (95% CI)	p-value
Age, years	0.99 (0.97 – 1.00)	0.083	0.99 (0.98 – 1.01)	0.57
Tumor size	1.19 (1.09 – 1.30)	<0.0001	1.16 (0.99 – 1.35)	0.064
Clinical stage
T1	1.00 (ref)		---	---
T2	1.90 (1.22 – 2.97)	0.005
LVI
absent	1.00 (ref)		1.00 (ref)
present	2.23 (1.44 – 3.45)	0.0003	2.03 (1.22 – 3.37)	0.0064
Tumor Grade
I	1.00 (ref)		1.00 (ref)
II	2.00 (1.20 – 3.34)	0.0078	2.33 (1.22 – 4.42)	0.0099
III	3.92 (2.37 – 6.48)	<0.0001	3.43 (1.67 – 7.04)	0.0008
HR status
negative	1.00 (ref)		1.00 (ref)
positive	0.51 (0.35 – 0.76)	0.001	1.08 (0.60 – 1.96)	0.79
Chemotherapy
no	1.00 (ref)		1.00 (ref)
yes	1.69 (1.16 – 2.46)	0.006	0.97 (0.59 – 1.59)	0.91
Hormonal therapy
no	1.00 (ref)		---	---
yes	0.72 (0.49 – 1.05)	0.087
Radiation therapy
no	1.00 (ref)		1.00 (ref)
yes	0.53 (0.30 – 0.93)	0.028	0.56 (0.29 – 1.08)	0.083

HR– hormone receptor; LVI– lymphovascular invasion