Table 2.
Pooled measures for the effect of the co-culture of pancreatic islets and MSCs on viability and ISI WMD.
| Viability |
ISI |
|||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Number of groups analyzed | I2 (%) | Pooled WMD (95% CI) | P-value* | Number of groups analyzed | I2 (%) | Pooled WMD (95% CI) | P-value* |
| Overall | 18 | 97.8 | 18.08 (12.59 – 23.57) | — | 15 | 69.3 | 0.83 (0.54 – 1.13) | — |
| Type of co-culture | < 0.001 | 0.224 | ||||||
| Indirect contact | 7 | 97.6 | 23.84 (15.99 – 31.69) | a | 4 | 75.9 | 1.10 (0.52 - 1.68) | |
| Direct contact | 7 | 52.5 | 5.93 (3.26 – 8.60) | b | 11 | 60.9 | 0.68 (0.35 – 1.02) | |
| Mixed contact | 4 | 98.2 | 28.84 (15.70 – 41.98) | a | — | — | — | |
| Islet origin | 0.907 | 0.493 | ||||||
| Murine | 17 | 97.9 | 18.05 (12.37 – 23.74) | 12 | 69.7 | 0.78 (0.44 – 1.12) | ||
| Pig | 1 | — | 18.60 (11.39 – 25.81) | — | — | — | ||
| Human | — | — | — | 3 | 73.0 | 1.11 (0.24 - 1.97) | ||
| MSCs origin | 0.332 | 0.114 | ||||||
| Murine | 16 | 97.9 | 18.71 (12.87 – 24.56) | 11 | 61.0 | 0.66 (0.35 – 0.98) | ||
| Human | 2 | 85.6 | 12.65 (1.87 – 23.43) | 4 | 72.9 | 1.23 (0.60 – 1.86) | ||
| MSCs tissue origin | 0.332 | < 0.001 | ||||||
| BM | 16 | 97.9 | 18.71 (12.87 – 24.56) | 13 | 53.7 | 0.65 (0.38 – 0.91) | ||
| UCB | — | — | — | 2 | 0.0 | 1.56 (1.17 – 1.96) | ||
| Adipose | 2 | 85.6 | 12.65 (1.87 – 23.43) | — | — | — | ||
MSC, mesenchymal stromal cells; ISI, insulin stimulation index; WMD, unstandardized weighted mean difference.
*
P-value for subgroup (univariate) analysis. Letters a and b refer to pairwise comparisons between co-culture contact system. Groups with different letters are significantly different (P < 0.05, Wald test).