Table 4.
Islet cell identity genes.
| Gene Title | Gene.Name | p-value | FC | Function |
|---|---|---|---|---|
| Differentially Expressed Genes | ||||
| SLCO5A1 | solute carrier organic anion transporter family, member 5A1 | 1.69E-05 | 2.98 | differentiation |
| CHGA | chromogranin A (parathyroid secretory protein 1) | 2.86E-03 | −1.23 | secretory cell marker |
| SYT13 | synaptotagmin XIII | 1.04E-04 | −1.29 | exocytosis |
| ABCC8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 0.011 | −1.31 | sulfonylurea – SUR1 receptor |
| STXBP1 | syntaxin binding protein 1 | 1.62E-03 | −1.33 | exocytosis |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.024 | −1.33 | cell differentiation and exocrine regeneration |
| SCAMP | secretory carrier membrane protein 1 | 4.96E-03 | −1.38 | secretory carrier membrane proteins |
| ISL1 | ISL LIM homeobox 1 | 0.045 | −1.39 | differentiation |
| PAX6 | paired box 6 | 0.013 | −1.46 | differentiation |
| NKX6–1 | NK6 homeobox 1 | 1.77E-03 | −1.51 | β cell maturation |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 4.18E-04 | −1.52 | β and α cell identity |
| KCNG3 | potassium voltage-gated channel modifier subfamily G member 3 | 3.11E-03 | −1.82 | cell viability, nuclear migration speed, ER |
| ARX | aristaless related homeobox | 1.17E-03 | −2.02 | α-cell marker |
| GRIN3A | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | 3.90E-06 | −3.76 | related to ion channels |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter), member 4, serotonin | 3.38E-03 | −3.92 | insulin secretion |
| Non-differentially Expressed Genes | ||||
| NKX2–2 | NK2 homeobox 2 | 0.149 | 1.33 | β cell development |
| SLC2A2 | solute carrier family 2 (facilitated glucose transporter), member 2 | 0.625 | 1.11 | glucose transporter 2 (GLUT2) |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.805 | 1.1 | key signaling pathway |
| NEUROD1 | neuronal differentiation 1 | 0.816 | −1.02 | β cell identity |
| FOXA2 | forkhead box A2 | 0.729 | −1.03 | important β cell transcription factor |
| SST | somatostatin | 0.84 | −1.03 | Inhibits insulin and glucagon secretion |
| INS | insulin | 0.515 | −1.05 | β cell product |
| GCG | glucagon | 0.324 | −1.06 | stimulates gluconeogenesis and glycogenolysis |
| PCSK2 | proprotein convertase subtilisin/kexin type 2 | 0.504 | −1.07 | proinsulin cleavage |
| NEUROG3 | neurogenin 3 | 0.219 | −1.08 | Islet cell development |
| IAPP | islet amyloid polypeptide | 0.408 | −1.11 | β cell secretory product |
| G6PC2 | glucose-6-phosphatase, catalytic, 2 | 0.551 | −1.13 | important for neogenesis |
| GCK | glucokinase (hexokinase 4) | 0.053 | −1.34 | glucose metabolism control |
The expression of some of the key transcription factors for β cells are downregulated, but no changes were seen for insulin, glucagon or somatostatin expression.