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Phosphorylation of STATs induced by R2016 and doxorubicin in LLC (A) and B16F10 (B) cell lines. Cells were treated for 18 hr with R2016 (1.5 μg/ml) and doxorubicin (0.01 μg/ml). Then level of intracellular phosphorylated-STAT1 (pSTAT1), pSTAT3 and pSTAT5 were measured by flow cytometry.
