Table 6. Differentially expressed genes located within ESX type VII secretion system loci.
| Functional Group | Description/Association | # of Genes | Hypergeometric Probability (FET p -value) | Range of Fold Change |
|---|---|---|---|---|
| ESX-1 (20)a | ESAT-6 secretion[33] | 5 (down) | 0.0321*(0.0434)** | -2.1 to -8.3 |
| ESX-2 (12) | Unknown | NDEb | NA | NA |
| ESX-3 (11) | Iron/Zinc homeostasis[33,34] | 5 (down) | 0.0024 (0.0028) | -2.5 to -4.9 |
| ESX-4 (7) | Most ancestral [35] | NDE | NA | NA |
| ESX-5 (17) | PE/PPE secretion [36–38] | 4 (down) | 0.0610 (0.0832) | -2.8 to -10.4 |
a Number within parentheses indicates total number of genes in the M. tb genome within this functional group
*Hypergeometric probability p value.
**Fisher’s exact test probability p value and bold numbers indicates statistical significance at p-value ≤ 0.05
bNot defined