Table 2. Patient Characteristics Associated with TB Incidence after ART Initiation.
| Original | Crude | Adjusted | ||||||
|---|---|---|---|---|---|---|---|---|
| N | Rate/100 | HR | 95%CI | p | AHR | 95% CI | p | |
| Year of ART Initiation | ||||||||
| 2004–2006 | 402 | 0.60 | 1.00 | 1.00 | ||||
| 2007–2009 | 1,953 | 0.50 | 0.48 | 0.29–0.80 | 0.007 | 0.45 | 0.20–1.01 | 0.052 |
| 2010–2012 | 1,126 | 0.83 | 0.55 | 0.25–1.23 | 0.143 | 0.62 | 0.29–1.35 | 0.218 |
| Age at Enrollment | ||||||||
| 15–24 | 390 | 0.60 | 1.00 | 1.00 | ||||
| 25–34 | 1,488 | 0.67 | 1.30 | 0.42–4.01 | 0.637 | 0.90 | 0.37–2.23 | 0.822 |
| 35–44 | 1,045 | 0.49 | 0.67 | 0.18–2.55 | 0.550 | 0.27 | 0.10–0.74 | 0.013 |
| 45+ | 556 | 0.49 | 0.65 | 0.14–2.96 | 0.565 | 0.26 | 0.06–1.18 | 0.078 |
| Gender* | ||||||||
| Female | 2,320 | 0.47 | 1.00 | |||||
| Male | 1,176 | 0.78 | 1.76 | 0.83–3.73 | 0.136 | - | - | - |
| Marital Status | ||||||||
| Single/Divorced/Widowed | 1,164 | 0.54 | 1.00 | 1.00 | ||||
| Married | 2,172 | 0.59 | 1.11 | 0.64–1.92 | 0.695 | 1.58 | 0.68–3.63 | 0.274 |
| Education Level | ||||||||
| None | 355 | 0.62 | 1.00 | 1.00 | ||||
| Primary | 685 | 0.76 | 2.31 | 0.52–10.31 | 0.264 | 1.41 | 0.27–7.34 | 0.674 |
| Secondary | 1,173 | 0.63 | 1.60 | 0.37–6.92 | 0.517 | 0.92 | 0.20–4.21 | 0.909 |
| Tertiary | 623 | 0.29 | 0.92 | 0.17–4.96 | 0.917 | 0.62 | 0.11–3.42 | 0.575 |
| Employment Status | ||||||||
| Employed | 1,797 | 0.59 | 1.00 | 1.00 | ||||
| Unemployed | 1,279 | 0.55 | 0.88 | 0.33–2.34 | 0.797 | 0.93 | 0.29–2.96 | 0.895 |
| Baseline CD4 count | ||||||||
| ≥ 200/μL | 1,054 | 0.29 | 1.00 | 1.00 | ||||
| 50- < 200/μL | 1,365 | 0.53 | 1.58 | 0.68–3.66 | 0.276 | 1.34 | 0.55–3.25 | 0.499 |
| < 50/μL | 429 | 1.62 | 4.89 | 1.51–15.84 | 0.010 | 4.17 | 1.36–12.72 | 0.014 |
| Baseline Weight | ||||||||
| <45kg | 404 | 0.69 | 1.00 | 1.00 | ||||
| 45-60kg | 1,716 | 0.66 | 0.83 | 0.26–2.64 | 0.741 | 0.96 | 0.26–3.60 | 0.952 |
| >60kg | 1,152 | 0.44 | 0.48 | 0.14–1.72 | 0.249 | 0.80 | 0.21–3.01 | 0.727 |
| WHO Stage | ||||||||
| Stage I | 845 | 0.30 | 1.00 | 1.00 | ||||
| Stage II | 850 | 0.64 | 2.58 | 0.86–7.70 | 0.087 | 1.88 | 0.64–5.48 | 0.238 |
| Stage III/IV | 1,569 | 0.72 | 2.17 | 0.77–6.12 | 0.137 | 0.62 | 0.28–1.68 | 0.337 |
| Functional Status | ||||||||
| Asymptomatic | 2,151 | 0.36 | 1.00 | 1.00 | ||||
| Symptoms but normal activity | 909 | 0.92 | 2.24 | 0.90–5.59 | 0.082 | 1.76 | 0.76–4.08 | 0.174 |
| Bedridden at all | 100 | 1.49 | 4.79 | 0.93–24.68 | 0.060 | 2.75 | 0.52–14.55 | 0.215 |
| TB Status at ART Initiation | ||||||||
| No TB | 2,789 | 0.27 | 1.00 | 1.00 | ||||
| Suspected TB | 226 | 4.52 | 11.2 | 5.47–22.75 | 0.000 | 12.23 | 4.46–33.50 | 0.000 |
| Prior TB | 41 | 3.94 | 16.3 | 3.23–82.16 | 0.001 | 17.64 | 3.54–87.88 | 0.001 |
* Some non-proportionality was identified with gender and so subsequent models were stratified by this variable