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. 2017 Mar 10;12(3):e0173264. doi: 10.1371/journal.pone.0173264

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© 2017 Maki et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — Coffee extract reduces the expression of the IRS1 protein by proteasomal degradation, thereby downregulating the activation of the MEK-ERK and Akt pathways. Thus, in cells treated with coffee extract, the phosphorylation of C/EBPβ mediated by ERK is inhibited and C/EBPβ is inactivated, which inhibits the expression of its target genes such as Pparγ, C/ebpα, Cdc45l, Mcm3, Gins1, and Cdc25, which are required for adipogenesis. E3 indicates E3 ubiquin ligase. Ub indicates ubiquitin.