Table 2. Distribution of rs9939609 genotypes according to diagnoses, along with relative odds ratios.
| GENETIC MODEL | ||||||||
|---|---|---|---|---|---|---|---|---|
| CO-DOMINANT MODEL | DOMINANT MODEL | RECESSIVE MODEL | ||||||
| Groups | No. | Genotype n (%) | Genotype n (%) | Genotype n (%) | ||||
| AA | AT | TT | AA +AT (coded as 1) | TT (coded as 0) | AA (coded as 1) | AT + TT (coded as 0) | ||
| Healthy controls | 119 | 16 (13.4%) | 47 (39.5%) | 56 (47.1%) | 63 (52.9%) | 56 (47.1%) | 16 (13.4%) | 103 (86,6%) |
| EDs | 250 | 73 (29.2%) | 109 (43.6%) | 68 (27.2%) | 182 (72.8%) | 68 (27.2%) | 73 (29.2%) | 177 (70,8%) |
| OR (CI) P | χ2 = 18.08; p<0.001 | χ2 = 14.2; p<0.001; OR 95% CI = 2.37; 1.50–3.75 | χ2 = 10.9; p = 0.001;OR 95% CI = 2.65; 1.46–4.80 | |||||
| BN | 116 | 43 (37.1%) | 41 (35.3%) | 32 (27.6%) | 84 (72.4%) | 32 (27.6%) | 43 (37.1%) | 73 (62,9%) |
| AN | 134 | 30 (22.4%) | 68 (50.7%) | 36 (26.9%) | 98 (73.1%) | 36 (26.9%) | 30 (22.4%) | 104 (77,6%) |
| OR (CI) P | Ns | χ2 = 0.02; p = 0.98; OR 95% CI = 1.03; 0.59–1.81 | χ2 = 6.48; p = 0.01; OR 95% CI = 2.04; 1.17–3.55 | |||||
| Binge eating patients | 172 | 58 (33.7%) | 74 (43.0%) | 40 (23.3%) | 132 (76.7%) | 40 (23.3%) | 58 (33.7%) | 114 (66,3%) |
| AN restricter | 78 | 15 (19.2%) | 35 (44.9%) | 28 (35.9%) | 50 (64.1%) | 28 (35.9%) | 15 (19.2%) | 63 (80,8%) |
| OR (CI) P | χ2 = 7.05; p = 0.02 | χ2 = 4.33; p = 0.037; OR 95% CI = 1.84; 1.03–3.30 | χ2 = 5.45; p = 0.020; OR 95% CI = 2.13; 1.12–4.07 | |||||
Legend: Binge eating patients include Bulimia Nervosa and Anorexia Nervosa binge/purge patients. ns: Not statistical significant.
Abbreviations: EDs: Eating Disorders; AN: Anorexia Nervosa; BN: Bulimia Nervosa.