Table 2a. Whole Blood Gene Expression Analysis to Predict Disease Activity in Patients with Crohn's Disease.
| Individual Gene | Gene Function/Association | |
|---|---|---|
| Crohn's Disease with Mild Severity | TAP2 (Transporter 2, ATP-Binding Cassettte, Sub-Family B) | Several autoimmune diseases including Rheumatoid Arthritis and Systemic Lupus Erythematosus |
| ZFAS1 (ZNFX1 Antisense RNA 1) | Breast cancer and intrahepatic cholangiocarcinoma | |
| SIAH1 (E3 Ubiquitin Protein Ligase 1) | Induced at the tip of intestinal villi, upregulated during physiologic apoptosis | |
| GMPR2 (Guanosine Monophosphate Reductase) | Gastric adenocarcinoma | |
| WAPAL (Wings Apart-Like Homolog) | Promotes release of cohesin from chromosomes, involved in mitotic prophase | |
| ZNF45 (Zinc Finger Protein 45) | Multiple sclerosis, may be involved DNA-dependent in transcriptional regulation | |
| Crohn's Disease with Moderate to Severe Disease | KANSL1 (KAT8 Regulatory NSL Complex Subunit1) | May be involved in the regulation of transciption; involved in the acetylation of nucleosomal histone H4 on lysine residues |
| PPP6C (Protein Phosphatase 6, Catalytic Subunit) | Regulates cell cycle progression in response to IL2 receptor stimulation | |
| LEPROTL1 (Leptin Receptor Overlapping Transcript-Like 1) | Believed to regulate the expression of growth hormone receptor cell surface in the liver | |
| MAP3K3 (Mitogen Activated Protein Kinase Kinase Kinase 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. | |
| SRA1 (Steroid receptor RNA activator 1) | A non-coding RNA that is able to co-activate steroid nuclear receptors | |
| ZNF45 (Zinc Finger Protein 45) | Multiple sclerosis, may be involved in DNA-dependent transcriptional regulation |
Burakoff R, Pabby V, Onyewadume L, et al. Blood-based Biomarkers Used to Predict Disease Activity in Crohn's Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2015;21(5):1132-1140.