Table 2b. Whole Blood Gene Expression Analysis to Predict Disease Activity in Patients with Ulcerative Colitis.
| Individual Gene | Gene Function/Association | |
|---|---|---|
| Ulcerative Colitis with Mild Severity | NLRP12 (Nucleotide-binding and oligomerization domain NOD-like receptors) | One of the members of the NOD-like receptor family of pattern recognition receptors. Plays a role in the production of IL-1β and IL-18 |
| TNFRSF10C (Tumor necrosis factor receptor super family, member 10c, decoy without an intracellular domain) | Functions as an antagonistic receptor that protects cells from TRAIL-induced apoptosis | |
| SRA1 (Steroid receptor RNA activator 1) | A non-coding RNA that is able to co-activate steroid nuclear receptors | |
| TAGAP (T-Cell Activation RhoGTPase Activating) | Plays a role in T-cell activation and migration | |
| PDE7A (Phosphodiesterase 7A) | A high-affinity cyclic AMP phosphodiesterase that is expressed in immune and pro-inflammatory cells | |
| ROPN1L (Rhophilin associated tail protein 1-like) | A protein-coding gene; elevated in breast cancer | |
| Ulcerative Colitis with Moderate to Severe Disease | CD24 (CD24 Molecule) | Modulates B-cell activation responses; CD24 C170T polymorphism is associated with IBD risk |
| HIST1H3H (Histone Cluster 1, H3h) | Plays a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability | |
| FDFT1 (Farnesyl-Diphosphate Farnesyltransferase) | Genetic factor associated with progression to NASH in patients with non-alcoholic steatosis | |
| PGM1 (Phosphoglucomutas 1) | Participates in both the breakdown and synthesis of glucose | |
| C14orf119 (Chromosome 14 Open Reading Frame 119) | Unknown | |
| RTFDC1 (Replication termination factor 2 domain containing 1) | Unknown |
Burakoff R, Pabby V, Onyewadume L, et al. Blood-based Biomarkers Used to Predict Disease Activity in Crohn's Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2015;21(5):1132-1140.