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. Author manuscript; available in PMC: 2017 Nov 22.
Published in final edited form as: Biochemistry. 2016 Nov 14;55(46):6363–6374. doi: 10.1021/acs.biochem.6b00635

Figure 2.

Figure 2

The general mechanistic strategy for NHFe enzymes, where a coordination position for O2 is only available when all cosubstrates are bound to the active site. Adapted from ref 2.