Table 1.

Tabulated clinical information regarding LSAOC and subsequent cancer diagnoses. Only cases with near complete data sets are shown. Abbreviations: NK: not known, CRC: colorectal cancer, AH: atypical hyperplasia, AC: adjuvant chemotherapy, EC: endometrial cancer, TCC: transitional cell carcinoma, RCC, renal cell carcinoma, DCIS: ductal carcinoma in situ. *signifies woman whose AH or EC was detected during gynecological surveillance and who was found to have a synchronous OC following hysterectomy and removal of both ovaries; ** signifies concurrent cancer diagnosis at time of LSAOC diagnosis. #signifies cause of death was attributed to OC. § is a patient with bi-allelic PMS2 mutation and therefore constitutional mismatch repair deficiency (CMMRD) rather than LS and is included here for information only.

ID	Mutation	Tumor	Age at diagnosis	Year of diagnosis	Screen detected	FIGO (2009)	Treatment	Outcome	Other Neoplasms
1	MLH1	Endometriod	42	2006	No	1b	Surgery	Alive	Nil
2	MLH1	Mixed	52	1997	No	2a	Surgery	Dead (1997)	Nil
3	MLH1	Clear cell	47	2004	No	1a	Surgery	Dead # (2006)	Nil
4	MLH1	Endometrioid	38	2012	No*	2c	Surgery	Alive	Dukes A CRC and AH**
5	MLH1	Endometrioid	37	1997	No	1b	Surgery + AC	Alive	Nil
6	MLH1	Clear cell	60	2005	No	2b	Surgery + AC	Alive	Nil
7	MLH1	Endometrioid	45	1960	No	1a	Surgery	Dead (1996)	EC**
8	MLH1	Endometrioid	46	1988	No	3a	Surgery	Dead # (1989)	EC**
9	MSH2	Endometrioid	24	1956	No	1a	Surgery	Alive	Breast (1991 &2006) Ureteric (1986) Skin (numerous) EC (1965)
10	MSH2	High grade serous	47	2003	No	1c	Surgery	Alive	EC**
11	MSH2	Mixed	33	2011	No	3c	Surgery + AC	Alive	Nil
12	MSH2	High grade serous	34	1973	No	2a	NK	Dead (1991)	Nil
13	MSH2	Endometrioid	41	2008	No*	1a	Surgery (?AC)	Alive	EC** Brenner tumor (benign) left ovary
14	MSH2	Other	48	2005	No	1a	Surgery + AC	Alive	Nil
15	MSH2	Clear cell	34	2005	Yes	1c	Surgery	Alive	Caecum Dukes CRC 32 Sigmoid Dukes CRC 34
16	MSH2	Endometrioid	51	2014	No	1a	Surgery + AC	Alive	Nil
17	MSH2	High grade serous	25	1988	No	1c	Surgery	Alive	Nil
18	MSH2	Endometrioid	42	1999	No	1a	Surgery	Dead# (2000)	Nil
19	MSH2	High grade serous	50	1999	No	1c	Surgery	Alive	Nil
20	MSH2	Endometrioid	41	2009	No	1c	Surgery	Alive	Nil
21	MSH2	Endometrioid	41	2012	No	1b	Surgery	Alive	Nil
22	MSH2	Carcinosarcoma	41	1994	No	2a	Surgery	Dead (1997)	EC**
23	MSH2	Endometrioid	51	2005	No	1c	Surgery	Dead# (2006)	Nil
24	MSH2	High grade serous	70	2005	No	3b	Surgery + AC	Alive	Dukes C CRC (1982) TCC bladder (2004) RCC (2007)
25	MSH2	Endometrioid	43	1997	No	1a	Surgery	Alive	DCIS (1989)
26	MSH2	Endometrioid	57	2011	No	2a	NK	Alive	EC**
27	MSH2	High grade serous	67	2006	No	1a	Surgery	Alive	TCC (1997)
28	MSH2	Endometrioid	41	2008	No*	1b	Surgery	Alive	EC**
29	MSH2	Clear cel	46	1984	No	NK	Surgery	Dead# (1985)	Oesophageal (1969)
30	MSH2	Endometrioid	55	1986	No	3a	Surgery	Dead (2011)	Duke C CRC (1989)
31	MSH2	Endometrioid	33	2004	Yes	1c	Surgery	Alive	Nil
32	MSH6	Mixed	67	2012	No	4	Surgery + AC	Dead# (2015)	Dukes B CRC (2012)
33	MSH6	Other	33	1971	No	1a	missing data	missing data	missing data
34	MSH6	Endometrioid	46	1992	No	1a	Surgery	Alive	Nil
35	MSH6	Mixed	49	2010	No	2a	Surgery + AC	Alive	Nil
36	MSH6	Endometrioid	44	2001	No	1b	Surgery + AC	Alive	Benign dermoid cyst right ovary
37 §	PMS2 (homozygote)	Mixed	27	2012	No	1c (both)	Surgery	Alive	Gastric Adenocarcinoma EC**