Cell cycle proteins as promising targets in cancer therapy

. Author manuscript; available in PMC: 2017 Jul 27.

Published in final edited form as: Nat Rev Cancer. 2017 Jan 27;17(2):93–115. doi: 10.1038/nrc.2016.138

CCND1 gain:	Hepatocellular carcinomas²⁵¹ Skin papillomas (DMBA)¹⁶ B-cell lymphomas²⁵² Mammary cancer¹³
CCND2 gain:	Skin carcinomas (DMBA+TPA)¹⁴
CCND3 gain:	Skin carcinomas (DMBA+TPA)¹⁴ Mammary cancer²⁵³
CDK4 gain:	Skin tumours (DMBA+TPA)^{12, 17} Pituitary, pancreatic tumours (Men1^+/−)⁵⁴ Pituitary carcinomas (Cdkn1b^−/−)²⁵⁴ Endocrine tumours, haemangiomas¹¹
CDK6 gain:	Skin papillomas (DMBA+TPA)¹⁵
CCNE1 gain:	Mammary cancer (Trp53^+/−)²⁵⁵ Mammary cancer⁴⁵ Lung cancer²⁵⁶ Lung cancer (Kras^G12D/+)²⁵⁷ Pituitary adenomas²⁵⁸ T-cell lymphomas (Cdkn1b^−/−)²⁵⁹
CCNB1/2 gain:	Lung cancer⁶⁴ Skin tumours (DMBA)⁶⁴ Intestinal adenocarcinomas (Apc^Min/+)⁶⁴
AURKA gain:	Skin carcinomas (DMBA+TPA)²⁶⁰ Mammary cancer¹⁰⁷
AURKB gain:	Lymphomas¹⁰²
Ccnd1 loss:	Intestinal adenomas (Apc^Min/+)²⁶¹ Skin carcinomas (v-Hras+TPA, DMBA+TPA)²⁶² Rhabdoid tumours (Ini1^+/−)²⁶³ Mammary cancer (Erbb2^V664D, v-Hras)^{18, 19} Mammary cancer (Erbb2^V664D)^{22, 26}
Ccnd2 loss:	Intestinal adenomas (Apc^Min/+)²⁶⁴ Ovarian, testicular, adrenal tumours (Inha^−/−)²⁶⁵ Skin carcinomas (DMBA+TPA)¹⁴
Ccnd3 loss:	T-cell ALL (Notch1^ICD)²⁶ T-cell ALL (LCK, Notch1^ICD)²³
Cdk4 loss:	Odontogenic tumours (Myc)²⁶⁶ Skin tumours (DMBA+TPA)²⁶⁷ Lung cancer (Kras^G12V/+)²⁵ Mammary cancer (Erbb2^V664D, v-Hras)^{20, 21, 268} Oligodendrogliomas (PDGF)²⁶⁹ B-cell lymphomas (Myc)²⁷⁰
Cdk6 loss:	Lymphomas (v-Akt1)²⁴
Ccna2 loss:	Liver tumours (NRAS^G12V+53-shRNA)²⁷¹
Cdk2 loss:	Skin tumours (CDK4+DMBA+TPA)⁵³ Mammary cancer (CCNE1^LMW, Erbb2^V664D)^{37, 58}
Cdk1 loss:	Liver tumours (NRAS^G12V)⁶⁵
Chek1 loss:	Mammary cancer (Wnt1, Trp53^+/−)^{77, 78} Skin carcinomas (DMBA+TPA)⁷⁹ Lymphomas (Chek2^+/−)²⁷² Skin papillomas (DMBA+TPA)⁷⁹ Mammary cancer (Trp53^+/−)⁷⁸
Chek2 loss:	B-cell lymphomas (Mus81^−/−)²⁷³ Skin tumours (DMBA)²⁷⁴ Lung cancer²⁷⁵ Mammary cancer (DMBA)²⁷⁵ Mammary cancer²⁷⁶ Mammary cancer (Brca1^−/−)²⁷⁷ T-cell lymphomas (Brca1^−/−)²⁷⁷ Lymphomas (Chek1^+/−)²⁷²
Wee1 loss:	Mammary cancer⁸⁷
Plk1 loss:	Lymphomas⁹⁵
Plk3 loss:	Lung adenocarcinomas²⁷⁸
Plk4 loss:	Hepatocellular carcinomas²⁷⁹ Lung adenocarcinomas²⁷⁹
Aurka loss:	Lymphomas¹⁰⁸
Aurkb loss:	Hepatocellular carcinomas, pituitary adenomas, skin papillomas¹⁰⁹