Fig. 1.

Effect of PCB-153 on glucose metabolism in vivo and in vitro. Mice were fed high fat diet (HFD) and drank water containing PCB-153. At the end of the experiment, fasting (A) and refed (B) blood glucose level was determined using a glucometer. IPGTT was conducted to evaluate glucose tolerance activity (C) and area under the curve was calculated (D). IPITT was conducted to evaluate insulin tolerance activity (E) and AUC was calculated (F). *p<0.05, significant differences between the two groups. AML-12 hepatocytes were treated by 0.5 and 1 μM PCB-153 for 24 h and the insulin-stimulated glucose uptake was evaluated and shown as folds of control (E). Differentiated 3T3-L1 adipocytes were treated by 0.5 and 1 μM PCB-153 for 24 h and the insulin-stimulated glucose uptake was evaluated and shown as folds of control (F). *p<0.05, significant differences compared with control.