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. 2017 Mar 7;12:300–310. doi: 10.1016/j.redox.2017.02.026

Fig. 3.

Fig. 3

Effect of PCB-153 on inflammation markers in vivo and in vitro. Mice were fed high fat diet (HFD) and drank water containing PCB-153. At the end of the experiment, mRNA expression of p65 subunit of NF-κB (A and E), nuclear and cytoplasmic protein expression of p65 subunit of NF-κB (B and F), mRNA expression of IL-1ɑ (C and G), and IL-6 (D and H) in livers and adipose tissues were determined. For protein expression, cropped blots were displayed. *p<0.05, significant differences between the two groups. AML-12 hepatocytes were treated by 0.5 and 1 μM PCB-153 for 24 h and mRNA expression of p65 subunit of NF-κB (I), nuclear and cytoplasmic protein expression of p65 subunit of NF-κB (J), mRNA expression of IL-1ɑ (K), and IL-6 (L) were determined. Differentiated 3T3-L1 adipocytes were treated by 0.5 and 1 μM PCB-153 for 24 h and mRNA expression of p65 subunit of NF-κB (M), nuclear protein expression of p65 subunit of NF-κB (N), mRNA expression of IL-1ɑ (O), and IL-6 (P) were determined. For protein expression, cropped blots were displayed. *p<0.05, significant differences compared with control.