Fig. 4.

Role of NF-κB in PCB-153-induced effect on inflammation, lipid accumulation and glucose uptake in hepatocytes and adipocytes. AML-12 hepatocytes and differentiated 3T3-L1 adipocytes were treated by 1 μM PCB-153 for 24 h with or without 10 μM BMS-345541, an inhibitor of NF-κB. mRNA expression of p65 subunit of NF-κB (A and B) were determined using real-time PCR. Results were shown as folds of control. TG content (C and D) and insulin-stimulated glucose uptake (E and F) were determined. *p<0.05, significant differences compared with control. **p<0.05, significant differences compared with PCB.