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. 2017 Mar 6;11:553–562. doi: 10.2147/DDDT.S113289

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© 2017 da Silva et al. This work is published and licensed by Dove Medical Press Limited

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Effect of LASSBio-294 on the blood pressure in infarcted SHRs (A) SBP, systolic blood pressure; (B) DBP, diastolic blood pressure; (C) MBP, mean blood pressure; (D) heart rate; (E) double product. SHR-Sham treated with DMSO and SHR-MI treated with DMSO or LASSBio-294 orally, 10 and 20 mg.kg⁻¹. Data are expressed as mean ± SEM.

Notes: *P<0.05 compared to SHR-Sham; **P<0.01 compared to SHR-Sham; ^&P<0.05 compared to SHR-MI; ^&&P<0.01 compared to SHR-MI, n=6.

Abbreviations: DBP, diastolic blood pressure; DMSO, dimethyl sulfoxide; MBP, mean blood pressure; SBP, systolic blood pressure; SHR, spontaneously hypertensive rats; LASSBio-294, 3,4-methylenedioxybenzoyl-2-thienylhydrazone; po, by mouth; MI, myocardial infarction.