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. Author manuscript; available in PMC: 2017 Mar 10.
Published in final edited form as: J Pathol. 2015 Nov 13;238(1):52–62. doi: 10.1002/path.4630

Figure 1. PCSK9 expression in murine peritoneal macrophages and LDLR degradation.

Figure 1

(A) mRNA levels of mPcsk9 and hPCSK9 in livers and MPM from WT and hPCSK9tg mice, as assessed by reverse transcription/PCR (B) hPCSK9 and mPcsk9 secretion in culture medium by MPM, as measured by ELISA (C) Flow cytometry analysis of surface LDLR levels in MPM from Control and hPCSK9tg mice. Student’s paired t-test was used for the analysis, ***p<0.0001. (D) Representative diagram of surface LDLR expression, as assessed by flow cytometry.