Figure 4. PCSK9 increases the expression of pro-inflammatory cytokines in LPS-stimulated MPM.
MPM were stimulated with LPS (50 ng/ml) for 4h. mRNA levels of Tnf (A), Il1b (B), Il10 (C) and Arg1 (D) in LPS-stimulated MPM from hPCSK9tg/apoE−/− and apoE−/− was analysed by RT-qPCR. Student’s paired t-test was used for the analysis, *p<0.05, **p<0.01.