Figure 5. PCSK9 increase in macrophage inflammation is LDLR-dependent.
MPM were stimulated with LPS (50 ng/ml) for 4h. mRNA levels of Tnf (A), Il1b (B), Il10 (C) and Arg1 (D) in LPS-stimulated MPM from hPCSK9tg/LDLR−/− and LDLR−/− was analysed by RT-qPCR. Student’s paired t-test was used for the analysis.