Table 2.
Annual and Average Annual Percentage Change in HCC Incidence Rates Over Time in the United States in Select Demographic Subgroups
| Joinpoint segment year start | Joinpoint segment year end | APC (95% CI) | P value | AAPC (95% CI) | P value | |
|---|---|---|---|---|---|---|
| Overall US population | 2000 | 2009 | 4.49 (4.28–4.70) | <.001 | 3.54 (3.30–3.78) | <.001 |
| 2009 | 2012 | 0.74 (−0.15 to 1.65) | .09 | |||
| Age-group at diagnosis, y | ||||||
| 20–24a | 2001 | 2012 | 0.99 (−2.84 to 4.97) | .58 | 0.99 (−2.84 to 4.97) | .58 |
| 25–29 | 2000 | 2002 | −7.92 (−48.81 to 65.64) | .61 | −0.01 (−8.77 to 9.59) | .998 |
| 25–29 | 2002 | 2007 | 7.38 (−10.33 to 28.60) | .23 | ||
| 25–29 | 2007 | 2010 | −11.06 (−47.40 to 50.39) | .44 | ||
| 25–29 | 2010 | 2012 | 8.27 (−36.76 to 85.37) | .59 | ||
| 30–34 | 2000 | 2004 | 8.25 (0.69–16.37) | .04 | 1.54 (−0.91 to 4.06) | .22 |
| 30–34 | 2004 | 2012 | −1.67 (−3.94 to 0.69) | .14 | ||
| 35–39 | 2000 | 2008 | 0.62 (−0.99 to 2.24) | .40 | −2.72 (−4.41 to −1.00) | .002 |
| 35–39 | 2008 | 2012 | −9.06 (−13.73 to −4.15) | .003 | ||
| 40–44 | 2000 | 2012 | −1.97 (−2.96 to −0.97) | .001 | −1.97 (−2.96 to −0.97) | .001 |
| 45–49 | 2000 | 2005 | 1.64 (−1.77 to 5.18) | .30 | −1.59 (−3.15 to −0.01) | .048 |
| 45–49 | 2005 | 2012 | −3.84 (−5.83 to −1.82) | .003 | ||
| 50–54 | 2000 | 2005 | 12.10 (8.91–15.40) | <.001 | 4.38 (2.46–6.23) | <.001 |
| 50–54 | 2005 | 2009 | 2.19 (−2.69 to 7.31) | .31 | ||
| 50–54 | 2009 | 2012 | −4.87 (−9.43 to −0.08) | .048 | ||
| 55–59 | 2000 | 2003 | 6.07 (−0.81 to 13.42) | .07 | 8.87 (7.06–10.72) | <.001 |
| 55–59 | 2003 | 2008 | 14.86 (11.53–18.30) | <.001 | ||
| 55–59 | 2008 | 2012 | 3.83 (1.55–6.17) | .007 | ||
| 60–64 | 2000 | 2003 | −0.56 (−7.40 to 6.80) | .86 | 6.44 (4.74–8.18) | <.001 |
| 60–64 | 2003 | 2012 | 8.89 (7.94–9.84) | <.001 | ||
| 65–69 | 2000 | 2012 | 3.11 (2.71–3.51) | <.001 | 3.11 (2.71–3.51) | <.001 |
| 70–74 | 2000 | 2012 | 2.20 (1.63–2.77) | <.001 | 2.20 (1.63–2.77) | <.001 |
| 75–79 | 2000 | 2008 | 3.60 (2.76–4.45) | <.001 | 2.12 (1.34–2.91) | <.001 |
| 75–79 | 2008 | 2012 | −0.79 (−2.92 to 1.39) | .43 | ||
| 80–84 | 2000 | 2012 | 2.63 (1.75–3.52) | <.001 | 2.63 (1.75–3.52) | <.001 |
| ≥85 | 2000 | 2012 | 1.83 (1.34–2.33) | <.001 | 1.83 (1.34–2.33) | <.001 |
| Sex | ||||||
| Female | 2000 | 2009 | 3.56 (3.14–3.99) | <.001 | 2.68 (2.18–3.17) | <.001 |
| Female | 2009 | 2012 | 0.05 (−1.82 to 1.96) | .95 | ||
| Male | 2000 | 2009 | 4.60 (4.26–4.93) | <.001 | 3.66 (3.29–4.03) | <.001 |
| Male | 2009 | 2012 | 0.91 (−0.48 to 2.31) | .17 | ||
| Race/ethnicity | ||||||
| AI/AN | 2000 | 2012 | 3.27 (0.97–5.63) | .009 | 3.27 (0.97–5.63) | .009 |
| API | 2000 | 2007 | 0.56 (−0.47 to 1.60) | .25 | −1.10 (−1.83 to −0.39) | .004 |
| API | 2007 | 2012 | −3.36 (−4.83 to −1.88) | .001 | ||
| Black/African American | 2000 | 2009 | 5.13 (4.25–6.03) | .000 | 3.92 (2.95–4.90) | <.001 |
| Black/African American | 2009 | 2012 | 0.37 (−3.19 to 4.07) | .82 | ||
| Latino/Hispanic | 2000 | 2010 | 3.04 (2.24–3.86) | <.001 | 2.00 (0.61–3.41) | .005 |
| Latino/Hispanic | 2010 | 2012 | −3.07 (−11.27 to 5.89) | .44 | ||
| White/Caucasian | 2000 | 2009 | 4.50 (4.29–4.71) | <.001 | 3.68 (3.45–3.92) | <.001 |
| White/Caucasian | 2009 | 2012 | 1.26 (0.36–2.17) | .01 |
NOTE. Results of joinpoint analyses.
AI/AN, American Indian or Alaska Native.
a
Data not available for 20- to 24-year-olds owing to sample size–related data privacy suppression.