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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Gastroenterology. 2016 Nov 23;152(4):812–820.e5. doi: 10.1053/j.gastro.2016.11.020

Table 3.

Age-Adjusted HCC Incidence Rates in Select US States and Subgroups

Joinpoint segment year start Joinpoint segment year end APC (95% CI) P value AAPC (95% CI) P value
Race/ethnicitya
API
Five most populous states in 2012
    California 2000 2007 1.13 (−1.40 to 3.72) .34 −1.61 (−3.40 to 0.21) .08
    California 2007 2012 −5.33 (−8.85 to −1.67) .01
    Floridab 2001 2012 −1.86 (−4.19 to 0.54) .11 −1.89 (−4.19 to 0.54) .11
    Hawaiic 2000 2012 0.48 (−0.74 to 1.72) .41 0.48 (−0.74 to 1.72) .41
    New York 2000 2012 −1.44 (−2.71 to −0.16) .03 −1.44 (−2.71 to −0.16) .03
    Texas 2000 2012 −1.04 (−2.70 to 0.66) .20 −1.04 (−2.70 to 0.66) .20
Black/African American
    California 2000 2012 2.37 (1.18–3.57) .001 2.37 (1.18–3.57) .001
    Florida 2000 2012 2.67 (0.67–4.70) .01 2.67 (0.67–4.70) .01
    Illinois 2000 2012 1.49 (−0.14 to 3.14) .07 −0.88 (−2.69 to 0.93) .34
    New York 2000 2012 4.15 (2.80–5.51) <.001 4.15 (2.80–5.51) <.001
    Texas 2000 2012 5.02 (3.44–6.63) <.001 5.02 (3.44–6.63) <.001
Latino/Hispanic
    California 2000 2012 2.66 (1.57–3.76) <.001 2.66 (1.57–3.76) <.001
    Florida 2000 2012 1.30 (0.08–2.54) .04 1.30 (0.08–2.54) .04
    Illinois 2000 2012 2.51 (0.02–5.07) .048 2.51 (0.02–5.07) .048
    New York 2000 2006 8.59 (5.47–11.79) <.001 1.66 (0.05–3.30) .04
    New York 2006 2012 −4.82 (−7.08 to −2.51) .001
    Texas 2000 2004 7.84 (1.32–14.78) .02 3.60 (1.57–5.67) <.001
    Texas 2004 2012 1.54 (−0.06 to 3.17) .057
White/Caucasian
    California 2000 2012 3.94 (3.05–4.83) <.001 3.94 (3.05–4.83) <.001
    Florida 2000 2012 3.46 (2.74–4.19) <.001 3.46 (2.74–4.19) <.001
    Illinois 2000 2012 2.65 (1.79–3.52) <.001 2.65 (1.79–3.52) <.001
    New York 2000 2012 1.91 (1.13–2.70) <.001 1.91 (1.13–2.70) <.001
    Texas 2000 2012 4.73 (4.19–5.28) <.001 4.73 (4.19–5.28) <.001
5 states largest increases in 5-year age-adjusted incidence rates (2008–2012)
5 states largest decreases increases in 5-year age-adjusted incidence rates (2008–2012)
State Incident HCC cases in 2012, n Population size in 2012 2012 Age-adjusted incidence/100,000a (95% CI) AAPC between 2008 and 2012 (95% CI), P value State Incident HCC cases in 2012, n Population size in 2012 2012 Age-adjusted incidence/100,000a (95% CI) AAPC between 2008 and 2012 (95% CI), P value
Kansas 206 2,885,398 6.13 (5.31–7.04) 7.83 (1.41–14.66), .03 Vermont 43 625,953 5.25 (3.75–7.20) −7.69 (−24.80 to 13.32), .30
Utah 116 2,854,871 4.71 (3.87–5.66) 7.17 (−4.56 to 20.35), .15 Virginia 484 8,186,628 5.11 (4.66–5.60) −4.68 (−10.56 to 1.58), .096
Idaho 95 1,595,590 5.20 (4.19–6.38) 5.93 (1.27–10.80), .03 Rhode Island 75 1,050,304 5.71 (4.47–7.22) −2.92 (12.44–7.64), .44
Arizona 565 6,551,149 7.22 (6.63–7.85) 5.64 (−0.09 to 11.71), .05 West Virginia 111 1,856,680 4.42 (3.62–5.36) −2.45 (−9.50 to 5.16), .37
Georgia 732 9,915,646 7.05 (6.53–7.59) 5.40 (−0.89 to 12.10), .07 Montana 50 1,005,494 3.76 (2.77–5.03) −1.16 (−11.355 to 10.21), .76

NOTE. Results of joinpoint analyses.

AI/AN, American Indian or Alaska Native.

a

Data for American Indian/Alaska Native not available at the state-level because the sample size required data suppression.

b

Data for 2000 not available for Florida in the United States Cancer Statistics registry.

c

Data from Hawaii included only for API.