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Mean ± SEM nicotine (A–D) and cotinine (E–H) AUC, half-life, non-renal, and total clearance according to UGT2B10 rs116294140 genotype is shown; All P-values indicated were derived from Kruskal-Wallis tests comparing UGT2B10 rs116294140 genotypes. Δ (% change) is calculated based on the value of (CC genotype – AA genotype)/AA genotype. Abbreviation: NIC, nicotine; AUC, area under the curve; CL, clearance; COT, cotinine; SEM, standard error of the mean.
