Table 6.
Plasma and urinary nicotine metabolite ratio by UGT2B10, UGT2B17 and FMO3 genotypes
| Genotype | Plasma 3HC/COT (d0)d |
Plasma 3HC/COT (d2)d |
Plasma 3HC/COT (d4)d |
Urinary total 3HC/free COT |
Urinary total 3HC/total COT |
|
|---|---|---|---|---|---|---|
| Meanb (SD) | Meanb (SD) | Meanb (SD) | Meanb (SD) | Meanb (SD) | ||
| UGT2B10 | AA (20)c | 0.31 (0.13) | 0.18 (0.09) | 0.18 (0.08) | 0.98 (0.88) | 0.68 (0.43) |
| (rs116294140) | AC (34) | 0.31 (0.20) | 0.17 (0.12) | 0.16 (0.11) | 0.87 (0.10) | 0.75 (0.50) |
| CC (6) | 0.20 (0.08) | 0.11 (0.05) | 0.10 (0.03) | 0.82 (0.21) | 0.80 (0.50) | |
| P-value | 0.22a | 0.23a | 0.06a | 0.99 | 0.77 | |
| UGT2B10 | GG (56) | 0.30 (0.17) | 0.17 (0.11) | 0.17 (0.10) | 0.91 (0.70) | 0.73 (0.47) |
| (rs61750900) | GT (4) | 0.27 (0.09) | 0.11 (0.03) | 0.12 (0.04) | 0.85 (0.56) | 0.82 (0.54) |
| TT (0) | NA | NA | NA | NA | NA | |
| P-value | 0.78a | 0.12a | 0.40a | 0.91 | 0.73 | |
| UGT2B17 | *1/*1 (27) | 0.31 (0.21) | 0.17 (0.14) | 0.17 (0.12) | 0.82 (0.59) | 0.73 (0.53) |
| (*2) | *1/*2 (28) | 0.29 (0.12) | 0.16 (0.78) | 0.16 (0.08) | 0.97 (0.74) | 0.75 (0.44) |
| *2/*2 (5) | 0.32 (0.16) | 0.15 (0.07) | 0.15 (0.06) | 0.92 (0.97) | 0.61 (0.43) | |
| P-value | 0.80a | 0.96a | 0.97a | 0.62 | 0.71 | |
| FMO3 | GG (24) | 0.29 (0.23) | 0.18 (0.15) | 0.16 (0.14) | 0.78 (0.69) | 0.73 (0.43) |
| (rs2266782) | GA (25) | 0.31 (0.15) | 0.17 (0.11) | 0.18 (0.08) | 0.94 (0.75) | 0.73 (0.43) |
| AA (11) | 0.28 (0.15) | 0.15 (0.08) | 0.14 (0.07) | 0.92 (0.64) | 0.74 (0.67) | |
| P-value | 0.58a | 0.77a | 0.17a | 0.64 | 0.85 | |
a
P-values are based on Mann-Whitney test or Kruskal-Wallis test with Bonferroni correction for multiple testing.
b
Arithmetic means are presented.
c
Genotype frequencies are presented in the brackets.
d
Plasma 3HC/COT ratio at 360 minutes based on the metabolites generated from tobacco use i.e. unlabeled (d0) as well as d2-, and d4-labeled compounds are presented.
Abbreviation: 3HC, 3-hydroxycotinine; COT, cotinine; SD, standard deviation.