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T. brucei MetRS inhibition assay. IC50s of both the positive control, Met-SA1, and compound 1 are <25 nM (the lower detection limit of the assay as described in the results and discussion). Error bars represent standard error of the mean of three replicates. Pentamidine, a negative control, had no T. brucei MetRS inhibition up to 10 µM (results not shown).
